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October 2018

Biochemistry Seminar – Michael Baym: “Evolutionary Approaches to Antibiotic Resistance”

October 24 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Michael Baym Department of Biomedical Informatics & Laboratory of Systems Pharmacology Harvard Medical School   Title: "Evolutionary Approaches to Antibiotic Resistance" Host:  BGA Location: 108 Biochemistry Building (Bldg#1507)

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Biochemistry Seminar- Charalampos Kalodimos: “Atomic view of regulation and drug resistance in Abi kinase”

October 31 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Charalampos Kalodimos Structural Biology St. Jude Children's Research Hospital   Title: "Atomic view of regulation and drug resistance in Abi kinase" Abstract: I will talk about using NMR to gain insights into the structure and dynamics of the conformational and energetic landscape of Abl kinase and how this information can reveal the mechanisms that underlie allosteric regulation and drug resistance. Host: Jae-Hyun Cho Location: 108 Biochemistry Building (Bldg#1507)

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November 2018

Biochemistry Seminar – Joshua Modell : “Bacterial and phage determinants of CRISPR-Cas acquired immunity”

November 7 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Department of Molecular Biology and Genetics Johns Hopkins School of Medicine Title: "Bacterial and phage determinants of CRISPR-Cas acquired immunity" Abstract: Bacterial CRISPR-Cas systems provide adaptive immunity against bacteriophages and plasmids by incorporating short ~30bp DNA sequences from these cellular invaders into the CRISPR locus. These molecular memories, or "spacers", are transcribed into guide RNAs which direct CRISPR effectors to cleave matching targets during subsequent encounters with foreign agents. My lab investigates how CRISPR systems interact with their bacterial hosts…

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Biochemistry Seminar – Fanxiu Zhu: “Subversion of cGAS-STING DNA sensing by Kaposi sarcoma-associated herpesvirus”

November 14 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Fanxiu Zhu Department of Biological Sciences Florida State University   Title: "Subversion of cGAS-STING DNA sensing by Kaposi sarcoma-associated herpesvirus" Abstract: Cytosolic DNAs of self or foreign are immuno-stimulatory that can be recognized by the host innate immune sensors. Among them cGAS (cyclic GMP-AMP synthase) is the principal one that upon binding to DNA can catalyze the synthesis of the cGAMP, a second messenger directs the adaptor protein STING to stimulate interferon immune responses. The cGAS-STING pathway plays a crucial…

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Biochemistry Seminar – Oleh Khalimonchuk : “Proteolytic control of mitochondrial shape and function”

November 28 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Oleh Khalimonchuk Department of Biochemistry University of Nebraska   Title: "Proteolytic control of mitochondrial shape and function" Abstract: Mitochondrial quality control (MQC) proteases are pivotal to mitochondrial functions and integrity. Despite their significance, our understanding of the multifaceted physiological roles and modus operandi of many MQC enzymes remains limited. Work in our lab, which focused mainly on the key MQC protease Oma1, used yeast and mammalian cell culture models and a blend of genetic, mechanistic biochemistry, and molecular cell biology…

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April 2019

Biochemistry Seminar – Alex Evilevitch: “Herpesvirus infectivity facilitated by internal DNA pressure and capsid stability”

April 17, 2019 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Alex Evilevitch Department of Pathobiology and Physics University of Illinois   Title:"Herpesvirus infectivity facilitated by internal DNA pressure and capsid stability" Abstract: Herpesviruses are a leading cause of human viral disease, second only to influenza and cold viruses. Herpesviruses consist of a double-stranded (ds) DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer (the tegument) and a lipid-envelope. During viral replication, an ATP-dependent motor packages the genome into a preformed capsid…

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Biochemistry Seminar – : “TBA”

April 24, 2019 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Title: "TBA" Abstract: Host: Location: 108 Biochemistry Building (Bldg#1507)

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