- Undergraduate Education
- A.B. Rice University (1968)
- Graduate Education
- Ph.D. University of Texas, Dallas (1975)
- Postdoc. Harvard Medical School (1975-78)
- Joined Texas A&M in 1978
Fundamental and Applied Phage Biology
The Young lab focuses on the molecular biology of bacteriophages, the viruses of bacteria. One major long-term interest is in the proteins and cell biology of host lysis, the terminal event in the phage infection cycle. Because this necessarily involves studying membrane phenomena and membrane proteins, researchers in the lab use a wide variety of techniques, including genetics, cell biology, biochemistry, genomics, and also collaborate intimately with laboratories involved in structural biology. The lab is also a charter member of TAMU’s unique Center for Phage Technology, dedicated to translational applications of phage biology in combating bacteria in the clinic, in agriculture and in industry. We participate fully in the CPT’s mission, including efforts to build an ethical and sustainable structure for the future of phage-based therapy for treating drug-resistant bacterial infections.
Cahill, J, Young, R. Phage Lysis: Multiple Genes for Multiple Barriers. Adv. Virus Res. 2019;103 :33-70.
Schooley, RT, Biswas, B, Gill, JJ, Hernandez-Morales, A, Lancaster, J, Lessor, L et al.. Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection". Antimicrob. Agents Chemother. 2018;62 (12):.
Chamakura, K, Young, R. Phage single-gene lysis: Finding the weak spot in the bacterial cell wall. J. Biol. Chem. 2019;294 (10):3350-3358.
Kongari, R, Rajaure, M, Cahill, J, Rasche, E, Mijalis, E, Berry, J et al.. Phage spanins: diversity, topological dynamics and gene convergence. BMC Bioinformatics. 2018;19 (1):326.
Kongari, R, Snowden, J, Berry, JD, Young, R. Localization and Regulation of the T1 Unimolecular Spanin. J. Virol. 2018;92 (22):.
Trinh, JT, Alkahtani, MH, Rampersaud, I, Rampersaud, A, Scully, M, Young, RF et al.. Fluorescent nanodiamond-bacteriophage conjugates maintain host specificity. Biotechnol. Bioeng. 2018;115 (6):1427-1436.
Gill, JJ, Wang, B, Sestak, E, Young, R, Chu, KH. Characterization of a Novel Tectivirus Phage Toil and Its Potential as an Agent for Biolipid Extraction. Sci Rep. 2018;8 (1):1062.
Hernandez-Morales, AC, Lessor, LL, Wood, TL, Migl, D, Mijalis, EM, Cahill, J et al.. Genomic and Biochemical Characterization of Acinetobacter Podophage Petty Reveals a Novel Lysis Mechanism and Tail-Associated Depolymerase Activity. J. Virol. 2018;92 (6):.
Cui, Z, Gorzelnik, KV, Chang, JY, Langlais, C, Jakana, J, Young, R et al.. Structures of Qβ virions, virus-like particles, and the Qβ-MurA complex reveal internal coat proteins and the mechanism of host lysis. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (44):11697-11702.
Chamakura, KR, Sham, LT, Davis, RM, Min, L, Cho, H, Ruiz, N et al.. A viral protein antibiotic inhibits lipid II flippase activity. Nat Microbiol. 2017;2 (11):1480-1484.