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Ry Young

Young, Ry
Ry Young
University Distinguished Professor, Professor of Biochemistry and Biophysics and Biology
Office:
BioBio / Room 311A
Email:
Phone:
979-845-2087
http://young.tamu.edu
Undergraduate Education
A.B. Rice University (1968)
Graduate Education
Ph.D. University of Texas, Dallas (1975)
Postdoc. Harvard Medical School (1975-78)
Joined Texas A&M in 1978

Fundamental and Applied Phage Biology

The Young lab focuses on the molecular biology of bacteriophages, the viruses of bacteria.  One major long-term interest is in the proteins and cell biology of host lysis, the terminal event in the phage infection cycle.  Because this necessarily involves studying membrane phenomena and membrane proteins, researchers in the lab use a wide variety of techniques, including genetics, cell biology, biochemistry, genomics, and also collaborate intimately with laboratories involved in structural biology. The lab is also a charter member of TAMU’s unique Center for Phage Technology, dedicated to translational applications of phage biology in combating bacteria in the clinic, in agriculture and in industry.  We participate fully in the CPT’s mission, including efforts to build an ethical and sustainable structure for the future of phage-based therapy for treating drug-resistant bacterial infections.

Recent Publications

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  1. Cahill, J, Young, R. Phage Lysis: Multiple Genes for Multiple Barriers. Adv. Virus Res. 2019;103 :33-70.
    doi: 10.1016/bs.aivir.2018.09.003. PubMed PMID:30635077. PubMed Central PMC6733033.

  2. Schooley, RT, Biswas, B, Gill, JJ, Hernandez-Morales, A, Lancaster, J, Lessor, L et al.. Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection". Antimicrob. Agents Chemother. 2018;62 (12):.
    doi: 10.1128/AAC.02221-18. PubMed PMID:30478181. PubMed Central PMC6256779.

  3. Chamakura, K, Young, R. Phage single-gene lysis: Finding the weak spot in the bacterial cell wall. J. Biol. Chem. 2019;294 (10):3350-3358.
    doi: 10.1074/jbc.TM118.001773. PubMed PMID:30420429. PubMed Central PMC6416421.

  4. Kongari, R, Rajaure, M, Cahill, J, Rasche, E, Mijalis, E, Berry, J et al.. Phage spanins: diversity, topological dynamics and gene convergence. BMC Bioinformatics. 2018;19 (1):326.
    doi: 10.1186/s12859-018-2342-8. PubMed PMID:30219026. PubMed Central PMC6139136.

  5. Kongari, R, Snowden, J, Berry, JD, Young, R. Localization and Regulation of the T1 Unimolecular Spanin. J. Virol. 2018;92 (22):.
    doi: 10.1128/JVI.00380-18. PubMed PMID:30135120. PubMed Central PMC6206483.

  6. Trinh, JT, Alkahtani, MH, Rampersaud, I, Rampersaud, A, Scully, M, Young, RF et al.. Fluorescent nanodiamond-bacteriophage conjugates maintain host specificity. Biotechnol. Bioeng. 2018;115 (6):1427-1436.
    doi: 10.1002/bit.26573. PubMed PMID:29460442. PubMed Central PMC5912989.

  7. Gill, JJ, Wang, B, Sestak, E, Young, R, Chu, KH. Characterization of a Novel Tectivirus Phage Toil and Its Potential as an Agent for Biolipid Extraction. Sci Rep. 2018;8 (1):1062.
    doi: 10.1038/s41598-018-19455-2. PubMed PMID:29348539. PubMed Central PMC5773508.

  8. Hernandez-Morales, AC, Lessor, LL, Wood, TL, Migl, D, Mijalis, EM, Cahill, J et al.. Genomic and Biochemical Characterization of Acinetobacter Podophage Petty Reveals a Novel Lysis Mechanism and Tail-Associated Depolymerase Activity. J. Virol. 2018;92 (6):.
    doi: 10.1128/JVI.01064-17. PubMed PMID:29298884. PubMed Central PMC5827379.

  9. Cui, Z, Gorzelnik, KV, Chang, JY, Langlais, C, Jakana, J, Young, R et al.. Structures of Qβ virions, virus-like particles, and the Qβ-MurA complex reveal internal coat proteins and the mechanism of host lysis. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (44):11697-11702.
    doi: 10.1073/pnas.1707102114. PubMed PMID:29078304. PubMed Central PMC5676892.

  10. Chamakura, KR, Sham, LT, Davis, RM, Min, L, Cho, H, Ruiz, N et al.. A viral protein antibiotic inhibits lipid II flippase activity. Nat Microbiol. 2017;2 (11):1480-1484.
    doi: 10.1038/s41564-017-0023-4. PubMed PMID:28894177. PubMed Central PMC5764540.

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