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David Threadgill

Threadgill, David
David Threadgill
University Distinguished Professor, Tom and Jean McMullin Chair of Genetics, Professor of Molecular and Cellular Medicine and of Biochemistry and Biophysics
Undergraduate Education
B.S., Texas A&M University, 1983
Graduate Education
Ph.D. Texas A&M University, 1989

Areas of Research

Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of the Erbb gene family in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.

Cancer genetics

We are focusing on colorectal, breast and kidney cancer to identify environmental factors and genetic polymorphisms contributing to differential susceptibility to the development and progression of cancer. We are also developing approaches to exploit these factors to prevent or delay cancer as well as to identify new therapies.

Epidermal growth factor receptor (Egfr)

We are using mouse models with genetically engineered or spontaneous mutations to elucidate the biological role of Egfr and other member of the Erbb gene family in vivo. These studies have lead to new insights into the role of these genes in neuronal survival and behavior, obesity, cancer and cardiovascular disease. We are currently performing mechanistic studies to identify how the Erbb genes contribute to normal and abnormal phenotypes.

Genetics of environmental responses

Just as individuals differ in their genetic constitution and disease susceptibility, they also differ in their responses toexogenous stimuli. We are using mouse models to investigate responses to environmental factors like the enteric flora of the gastrointestinal tract, diet, and toxicants like dioxin, trichloroethylene, and arsenic. The goal of these studies is to identify how individual responses to environmental factors leads to differential disease susceptibilities and methods to prevent disease in exposed individuals.

Systems genetics resources

We are participating in a large international effort to develop and exploit a new mouse genetic resources that will support the integration of genetics into systems biological analyses at the whole animal level. These efforts are based upon the Collaborative Cross, which is a unique recombinant inbred population of mice that have randomly assorted the genetic polymorphisms present in the eight founder inbred strains. A major focus of our work is the development and use of cell-based platforms for in vitro genetic studies.

Recent Publications

  1. Orzabal, MR, Lunde-Young, ER, Ramirez, JI, Howe, SYF, Naik, VD, Lee, J et al.. Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits. Transl Res. 2019; :.
    doi: 10.1016/j.trsl.2019.01.001. PubMed PMID:30653941. .

  2. Cuomo, D, Porreca, I, Ceccarelli, M, Threadgill, DW, Barrington, WT, Petriella, A et al.. Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions. Cell Death Discov. 2018;4 :112.
    doi: 10.1038/s41420-018-0121-y. PubMed PMID:30534420. PubMed Central PMC6281605.

  3. Dornbos, P, Warren, M, Crawford, RB, Kaminski, NE, Threadgill, DW, LaPres, JJ et al.. Characterizing Serpinb2 as a Modulator of TCDD-Induced Suppression of the B Cell. Chem. Res. Toxicol. 2018;31 (11):1248-1259.
    doi: 10.1021/acs.chemrestox.8b00225. PubMed PMID:30339366. .

  4. Garbutt, TA, Konneker, TI, Konganti, K, Hillhouse, AE, Swift-Haire, F, Jones, A et al.. Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus. Sci Rep. 2018;8 (1):14706.
    doi: 10.1038/s41598-018-32116-8. PubMed PMID:30279419. PubMed Central PMC6168588.

  5. Cichocki, JA, Luo, YS, Furuya, S, Venkatratnam, A, Konganti, K, Chiu, WA et al.. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol. Sci. 2019;167 (1):126-137.
    doi: 10.1093/toxsci/kfy223. PubMed PMID:30202895. PubMed Central PMC6317418.

  6. Konganti, K, Ehrlich, A, Rusyn, I, Threadgill, DW. gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population. G3 (Bethesda). 2018;8 (8):2559-2562.
    doi: 10.1534/g3.118.200230. PubMed PMID:29880557. PubMed Central PMC6071593.

  7. Konganti, K, Guerrero, FD, Schilkey, F, Ngam, P, Jacobi, JL, Umale, PE et al.. A Whole Genome Assembly of the Horn Fly, Haematobia irritans, and Prediction of Genes with Roles in Metabolism and Sex Determination. G3 (Bethesda). 2018;8 (5):1675-1686.
    doi: 10.1534/g3.118.200154. PubMed PMID:29602812. PubMed Central PMC5940159.

  8. Wells, A, Barrington, WT, Dearth, S, May, A, Threadgill, DW, Campagna, SR et al.. Tissue Level Diet and Sex-by-Diet Interactions Reveal Unique Metabolite and Clustering Profiles Using Untargeted Liquid Chromatography-Mass Spectrometry on Adipose, Skeletal Muscle, and Liver Tissue in C57BL6/J Mice. J. Proteome Res. 2018;17 (3):1077-1090.
    doi: 10.1021/acs.jproteome.7b00750. PubMed PMID:29373032. .

  9. Venkatratnam, A, House, JS, Konganti, K, McKenney, C, Threadgill, DW, Chiu, WA et al.. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mamm. Genome. 2018;29 (1-2):168-181.
    doi: 10.1007/s00335-018-9734-y. PubMed PMID:29353386. PubMed Central PMC6094947.

  10. Gao, Y, Fang, X, Vincent, DF, Threadgill, DW, Bartholin, L, Li, Q et al.. Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling. Reprod. Biol. Endocrinol. 2017;15 (1):94.
    doi: 10.1186/s12958-017-0312-z. PubMed PMID:29221447. PubMed Central PMC5723096.

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