- Steven Safe
- Distinguished Professor of Veterinary Physiology and Pharmacology and of Biochemistry and Biophysics Syd Kyle Chair in Veterinary Medicine
- VB / Room 410
- Undergraduate Education
- B.S. Queens University (1962)
- Graduate Education
- D.Phil. Oxford University (1966)
- Postdoc. Oxford and Harvard Universities (1966-68)
- Joined Texas A&M in 1981
Molecular Biology of Endocrine Disruption Chemicals
The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.
Afzali, MF, Popichak, KA, Burton, LH, Klochak, AL, Wilson, WJ, Safe, S et al.. A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism. Mol. Immunol. 2018;101 :46-54.
Jin, UH, Karki, K, Kim, SB, Safe, S. Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK. Biochem. Biophys. Res. Commun. 2018;501 (3):751-757.
Mohankumar, K, Lee, J, Wu, CS, Sun, Y, Safe, S. Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells. Endocrinology. 2018;159 (5):1950-1963.
Hammond, SL, Popichak, KA, Li, X, Hunt, LG, Richman, EH, Damale, PU et al.. The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. J. Pharmacol. Exp. Ther. 2018;365 (3):636-651.
Draz, H, Goldberg, AA, Tomlinson Guns, ES, Fazli, L, Safe, S, Sanderson, JT et al.. Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model. Invest New Drugs. 2018; :.
Jin, UH, Park, H, Li, X, Davidson, LA, Allred, C, Patil, B et al.. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones. Toxicol. Sci. 2018; :.
Safe, S, Abbruzzese, J, Abdelrahim, M, Hedrick, E. Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development. Cancer Prev Res (Phila). 2018; :.
Choudhary, M, Safe, S, Malek, G. Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. Biochim. Biophys. Acta. 2018;1864 (5 Pt A):1583-1595.
Cheng, Y, Imanirad, P, Jutooru, I, Hedrick, E, Jin, UH, Rodrigues Hoffman, A et al.. Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. PLoS ONE. 2018;13 (2):e0192264.
Safe, S, Nair, V, Karki, K. Metformin-induced anticancer activities: recent insights. Biol. Chem. 2018;399 (4):321-335.