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James Sacchettini

Sacchettini, James
James Sacchettini
Professor of Biochemistry and Biophysics and of Chemistry; Wolfe-Welch Chair in Science
ILSB / Room 2138A
Undergraduate Education
B.A St. Louis University (1980)
Graduate Education
Ph.D. Washington University, St. Louis (1987)
Postdoc. Washington University, St. Louis (1987-89)
Professor. Albert Einstein College of Medicine
Joined Texas A&M in 1996

Crystallography / Drug Design

My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.

Recent Publications

  1. Chen, Q, Shah, KN, Zhang, F, Salazar, AJ, Shah, PN, Li, R et al.. Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa. Mol. Pharm. 2019; :.
    doi: 10.1021/acs.molpharmaceut.8b01288. PubMed PMID:30817887. .

  2. Salazar, AJ, Sherekar, M, Tsai, J, Sacchettini, JC. R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold. PLoS ONE. 2019;14 (2):e0211432.
    doi: 10.1371/journal.pone.0211432. PubMed PMID:30721244. PubMed Central PMC6363177.

  3. Ballinger, E, Mosior, J, Hartman, T, Burns-Huang, K, Gold, B, Morris, R et al.. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science. 2019;363 (6426):.
    doi: 10.1126/science.aau8959. PubMed PMID:30705156. .

  4. Miller, BK, Hughes, R, Ligon, LS, Rigel, NW, Malik, S, Anjuwon-Foster, BR et al.. Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway. Elife. 2019;8 :.
    doi: 10.7554/eLife.40063. PubMed PMID:30604681. PubMed Central PMC6333443.

  5. Xia, Y, Zhou, Y, Carter, DS, McNeil, MB, Choi, W, Halladay, J et al.. Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. Life Sci Alliance. 2018;1 (3):e201800025.
    doi: 10.26508/lsa.201800025. PubMed PMID:30456352. PubMed Central PMC6238539.

  6. Daniel-Wayman, S, Abate, G, Barber, DL, Bermudez, LE, Coler, RN, Cynamon, MH et al.. Advancing Translational Science for Pulmonary NTM Infections: A Roadmap for Research. Am. J. Respir. Crit. Care Med. 2018; :.
    doi: 10.1164/rccm.201807-1273PP. PubMed PMID:30428263. .

  7. Rittershaus, ESC, Baek, SH, Krieger, IV, Nelson, SJ, Cheng, YS, Nambi, S et al.. A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis. Cell Chem Biol. 2018;25 (12):1495-1505.e3.
    doi: 10.1016/j.chembiol.2018.09.009. PubMed PMID:30318462. PubMed Central PMC6309504.

  8. Melief, E, Kokoczka, R, Files, M, Bailey, MA, Alling, T, Li, H et al.. Construction of an overexpression library for Mycobacterium tuberculosis. Biol Methods Protoc. 2018;3 (1):bpy009.
    doi: 10.1093/biomethods/bpy009. PubMed PMID:30197930. PubMed Central PMC6118195.

  9. Ellenbarger, JF, Krieger, IV, Huang, HL, Gómez-Coca, S, Ioerger, TR, Sacchettini, JC et al.. Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids. J Chem Inf Model. 2018;58 (10):2085-2091.
    doi: 10.1021/acs.jcim.8b00417. PubMed PMID:30137983. .

  10. Shen, Q, Bhatt, VS, Krieger, I, Sacchettini, JC, Cho, JH. Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase. Medchemcomm. 2018;9 (3):519-524.
    doi: 10.1039/c7md00619e. PubMed PMID:30108942. PubMed Central PMC6072116.

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