- Undergraduate Education
- B.A St. Louis University (1980)
- Graduate Education
- Ph.D. Washington University, St. Louis (1987)
- Postdoc. Washington University, St. Louis (1987-89)
- Professor. Albert Einstein College of Medicine
- Joined Texas A&M in 1996
Crystallography / Drug Design
My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.
Xia, Y, Zhou, Y, Carter, DS, McNeil, MB, Choi, W, Halladay, J et al.. Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. Life Sci Alliance. 2018;1 (3):e201800025.
Daniel-Wayman, S, Abate, G, Barber, DL, Bermudez, LE, Coler, RN, Cynamon, MH et al.. Advancing Translational Science for Pulmonary NTM Infections: A Roadmap for Research. Am. J. Respir. Crit. Care Med. 2018; :.
Rittershaus, ESC, Baek, SH, Krieger, IV, Nelson, SJ, Cheng, YS, Nambi, S et al.. A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis. Cell Chem Biol. 2018; :.
Melief, E, Kokoczka, R, Files, M, Bailey, MA, Alling, T, Li, H et al.. Construction of an overexpression library for Mycobacterium tuberculosis. Biol Methods Protoc. 2018;3 (1):bpy009.
Ellenbarger, JF, Krieger, IV, Huang, HL, Gómez-Coca, S, Ioerger, TR, Sacchettini, JC et al.. Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids. J Chem Inf Model. 2018;58 (10):2085-2091.
Shen, Q, Bhatt, VS, Krieger, I, Sacchettini, JC, Cho, JH. Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase. Medchemcomm. 2018;9 (3):519-524.
Blanc, L, Sarathy, JP, Alvarez Cabrera, N, O'Brien, P, Dias-Freedman, I, Mina, M et al.. Impact of immunopathology on the antituberculous activity of pyrazinamide. J. Exp. Med. 2018;215 (8):1975-1986.
Singh, SB, Odingo, J, Bailey, MA, Sunde, B, Korkegian, A, O'Malley, T et al.. Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis. BMC Res Notes. 2018;11 (1):416.
Ganley, JG, Carr, G, Ioerger, TR, Sacchettini, JC, Clardy, J, Derbyshire, ER et al.. Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. Chembiochem. 2018;19 (15):1590-1594.
Tiwari, D, Park, SW, Essawy, MM, Dawadi, S, Mason, A, Nandakumar, M et al.. Targeting protein biotinylation enhances tuberculosis chemotherapy. Sci Transl Med. 2018;10 (438):.