- Undergraduate Education
- B.A St. Louis University (1980)
- Graduate Education
- Ph.D. Washington University, St. Louis (1987)
- Postdoc. Washington University, St. Louis (1987-89)
- Professor. Albert Einstein College of Medicine
- Joined Texas A&M in 1996
Crystallography / Drug Design
My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.
Guthrie, LM, Soma, S, Yuan, S, Silva, A, Zulkifli, M, Snavely, TC et al.. Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice. Science. 2020;368 (6491):620-625.
Jansen, RS, Mandyoli, L, Hughes, R, Wakabayashi, S, Pinkham, JT, Selbach, B et al.. Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis. Nat Commun. 2020;11 (1):1960.
Taira, J, Umei, T, Inoue, K, Kitamura, M, Berenger, F, Sacchettini, JC et al.. Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening. J. Antibiot. 2020;73 (6):372-381.
Sun, Q, Li, X, Perez, LM, Shi, W, Zhang, Y, Sacchettini, JC et al.. The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun. 2020;11 (1):339.
Mosior, J, Bourland, R, Soma, S, Nathan, C, Sacchettini, J. Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis. Protein Sci. 2020;29 (3):744-757.
Tang, S, Hicks, ND, Cheng, YS, Silva, A, Fortune, SM, Sacchettini, JC et al.. Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res. 2019;47 (18):9934-9949.
Dragset, MS, Ioerger, TR, Zhang, YJ, Mærk, M, Ginbot, Z, Sacchettini, JC et al.. Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness. Sci Rep. 2019;9 (1):11394.
Carey, AF, Rock, JM, Krieger, IV, Chase, MR, Fernandez-Suarez, M, Gagneux, S et al.. Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. PLoS Pathog. 2019;15 (6):e1007846.
Brown, EE, Miller, AK, Krieger, IV, Otto, RM, Sacchettini, JC, Herman, JK et al.. A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation. J. Bacteriol. 2019;201 (16):.
Farhat, MR, Freschi, L, Calderon, R, Ioerger, T, Snyder, M, Meehan, CJ et al.. GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions. Nat Commun. 2019;10 (1):2128.