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James Sacchettini

Sacchettini, James
James Sacchettini
Professor of Biochemistry and Biophysics and of Chemistry; Wolfe-Welch Chair in Science
ILSB / Room 2138A
Undergraduate Education
B.A St. Louis University (1980)
Graduate Education
Ph.D. Washington University, St. Louis (1987)
Postdoc. Washington University, St. Louis (1987-89)
Professor. Albert Einstein College of Medicine
Joined Texas A&M in 1996

Crystallography / Drug Design

My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.

Recent Publications

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  1. Tang, S, Hicks, ND, Cheng, YS, Silva, A, Fortune, SM, Sacchettini, JC et al.. Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res. 2019;47 (18):9934-9949.
    doi: 10.1093/nar/gkz724. PubMed PMID:31504787. PubMed Central PMC6765138.

  2. Dragset, MS, Ioerger, TR, Zhang, YJ, Mærk, M, Ginbot, Z, Sacchettini, JC et al.. Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness. Sci Rep. 2019;9 (1):11394.
    doi: 10.1038/s41598-019-47905-y. PubMed PMID:31388080. PubMed Central PMC6684656.

  3. Carey, AF, Rock, JM, Krieger, IV, Chase, MR, Fernandez-Suarez, M, Gagneux, S et al.. Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. PLoS Pathog. 2019;15 (6):e1007846.
    doi: 10.1371/journal.ppat.1007846. PubMed PMID:31163081. PubMed Central PMC6548391.

  4. Brown, EE, Miller, AK, Krieger, IV, Otto, RM, Sacchettini, JC, Herman, JK et al.. A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation. J. Bacteriol. 2019;201 (16):.
    doi: 10.1128/JB.00287-19. PubMed PMID:31160399. PubMed Central PMC6657595.

  5. Farhat, MR, Freschi, L, Calderon, R, Ioerger, T, Snyder, M, Meehan, CJ et al.. GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions. Nat Commun. 2019;10 (1):2128.
    doi: 10.1038/s41467-019-10110-6. PubMed PMID:31086182. PubMed Central PMC6513847.

  6. Crespo, RA, Dang, Q, Zhou, NE, Guthrie, LM, Snavely, TC, Dong, W et al.. Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. J. Med. Chem. 2019;62 (9):4483-4499.
    doi: 10.1021/acs.jmedchem.9b00020. PubMed PMID:31002508. PubMed Central PMC6511943.

  7. Dixit, A, Freschi, L, Vargas, R, Calderon, R, Sacchettini, J, Drobniewski, F et al.. Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting. Sci Rep. 2019;9 (1):5602.
    doi: 10.1038/s41598-019-41967-8. PubMed PMID:30944370. PubMed Central PMC6447560.

  8. Chen, Q, Shah, KN, Zhang, F, Salazar, AJ, Shah, PN, Li, R et al.. Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa. Mol. Pharm. 2019;16 (4):1606-1619.
    doi: 10.1021/acs.molpharmaceut.8b01288. PubMed PMID:30817887. .

  9. Salazar, AJ, Sherekar, M, Tsai, J, Sacchettini, JC. R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold. PLoS ONE. 2019;14 (2):e0211432.
    doi: 10.1371/journal.pone.0211432. PubMed PMID:30721244. PubMed Central PMC6363177.

  10. Ballinger, E, Mosior, J, Hartman, T, Burns-Huang, K, Gold, B, Morris, R et al.. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science. 2019;363 (6426):.
    doi: 10.1126/science.aau8959. PubMed PMID:30705156. PubMed Central PMC6613350.

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