- Undergraduate Education
- B.A St. Louis University (1980)
- Graduate Education
- Ph.D. Washington University, St. Louis (1987)
- Postdoc. Washington University, St. Louis (1987-89)
- Professor. Albert Einstein College of Medicine
- Joined Texas A&M in 1996
Crystallography / Drug Design
My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.
Thapa, HR, Tang, S, Sacchettini, JC, Devarenne, TP. Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L. ACS Chem. Biol. 2017;12 (9):2408-2416.
Pham, TV, Murkin, AS, Moynihan, MM, Harris, L, Tyler, PC, Shetty, N et al.. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (29):7617-7622.
Patel, N, O'Malley, T, Zhang, YK, Xia, Y, Sunde, B, Flint, L et al.. A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro. Antimicrob. Agents Chemother. 2017;61 (9):.
Aggarwal, A, Parai, MK, Shetty, N, Wallis, D, Woolhiser, L, Hastings, C et al.. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017;170 (2):249-259.e25.
Perkowski, EF, Zulauf, KE, Weerakoon, D, Hayden, JD, Ioerger, TR, Oreper, D et al.. Erratum for Perkowski et al., "The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection". MBio. 2017;8 (3):.
Perkowski, EF, Zulauf, KE, Weerakoon, D, Hayden, JD, Ioerger, TR, Oreper, D et al.. The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection. MBio. 2017;8 (2):.
Puckett, S, Trujillo, C, Wang, Z, Eoh, H, Ioerger, TR, Krieger, I et al.. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (11):E2225-E2232.
Zhu, M, Harshbarger, WD, Robles, O, Krysiak, J, Hull, KG, Cho, SW et al.. A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids. Bioorg. Med. Chem. 2017;25 (11):2901-2916.
Gomez, JE, Kaufmann-Malaga, BB, Wivagg, CN, Kim, PB, Silvis, MR, Renedo, N et al.. Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. Elife. 2017;6 :.
Huang, HL, Krieger, IV, Parai, MK, Gawandi, VB, Sacchettini, JC. Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem. 2016;291 (53):27421-27432.