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James Sacchettini

Sacchettini, James
James Sacchettini
Professor of Biochemistry and Biophysics and of Chemistry; Wolfe-Welch Chair in Science
Office:
ILSB / Room 2138A
Email:
Phone:
979-862-7636
http://www.sacclab.com
Undergraduate Education
B.A St. Louis University (1980)
Graduate Education
Ph.D. Washington University, St. Louis (1987)
Postdoc. Washington University, St. Louis (1987-89)
Professor. Albert Einstein College of Medicine
Joined Texas A&M in 1996

Crystallography / Drug Design

My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.

Recent Publications

  1. Lehmann, J, Cheng, TY, Aggarwal, A, Park, AS, Zeiler, E, Raju, RM et al.. An antibacterial ╬▓-lactone kills Mycobacterium tuberculosis by infiltrating mycolic acid biosynthesis. Angew. Chem. Int. Ed. Engl. 2017; :.
    doi: 10.1002/anie.201709365. PubMed PMID:29067779. .

  2. Chandrasekera, NS, Berube, BJ, Shetye, G, Chettiar, S, O'Malley, T, Manning, A et al.. Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB. ACS Infect Dis. 2017; :.
    doi: 10.1021/acsinfecdis.7b00112. PubMed PMID:29035551. .

  3. Yang, K, Chang, JY, Cui, Z, Li, X, Meng, R, Duan, L et al.. Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. 2017;45 (18):10884-10894.
    doi: 10.1093/nar/gkx785. PubMed PMID:28977617. .

  4. Taira, J, Morita, K, Kawashima, S, Umei, T, Baba, H, Maruoka, T et al.. Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening. J. Antibiot. 2017;70 (11):1057-1064.
    doi: 10.1038/ja.2017.106. PubMed PMID:28951604. .

  5. Yadon, AN, Maharaj, K, Adamson, JH, Lai, YP, Sacchettini, JC, Ioerger, TR et al.. A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. Nat Commun. 2017;8 (1):588.
    doi: 10.1038/s41467-017-00721-2. PubMed PMID:28928454. PubMed Central PMC5605632.

  6. Thapa, HR, Tang, S, Sacchettini, JC, Devarenne, TP. Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L. ACS Chem. Biol. 2017;12 (9):2408-2416.
    doi: 10.1021/acschembio.7b00457. PubMed PMID:28813599. .

  7. Pham, TV, Murkin, AS, Moynihan, MM, Harris, L, Tyler, PC, Shetty, N et al.. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (29):7617-7622.
    doi: 10.1073/pnas.1706134114. PubMed PMID:28679637. PubMed Central PMC5530696.

  8. Patel, N, O'Malley, T, Zhang, YK, Xia, Y, Sunde, B, Flint, L et al.. A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro. Antimicrob. Agents Chemother. 2017;61 (9):.
    doi: 10.1128/AAC.01205-17. PubMed PMID:28674058. PubMed Central PMC5571309.

  9. Aggarwal, A, Parai, MK, Shetty, N, Wallis, D, Woolhiser, L, Hastings, C et al.. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017;170 (2):249-259.e25.
    doi: 10.1016/j.cell.2017.06.025. PubMed PMID:28669536. PubMed Central PMC5509550.

  10. Perkowski, EF, Zulauf, KE, Weerakoon, D, Hayden, JD, Ioerger, TR, Oreper, D et al.. Erratum for Perkowski et al., "The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection". MBio. 2017;8 (3):.
    doi: 10.1128/mBio.00872-17. PubMed PMID:28634243. PubMed Central PMC5478898.

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