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Michael Polymenis

Polymenis, Michael
Michael Polymenis
BioBio / Room 333A
Undergraduate Education
B.S. University of Patras, Greece (1988)
Graduate Education
Ph.D. Tufts University Medical School (1994)
Postdoc. Massachusetts General Hospital Cancer Center, Harvard Medical School (1995-1999)
Joined Texas A&M in 1999

Coordination of Cell growth with Cell Division

The promise for the treatment of proliferative disorders, with incalculable potential benefits to human health, has driven basic research into the genetic control of cell division for decades. However, what determines when cells initiate their division remains mysterious. It is as if we are staring at a beautiful engine, with little knowledge about what turns it on. How cells are set off to a new round of cell division, remains as one of the most fundamental, unanswered questions. It is virtually unknown which cellular pathways affect initiation of division, which factors operate within each pathway, the extent of interactions between pathways, and how each pathway is molecularly linked to the machinery of cell division. Our studies aim to answer these questions using baker’s yeast. This model organism has a machinery of cell division that is very similar to that of human cells, and it is suited for genetic and biochemical studies.

Recent Publications

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  1. Maitra, N, He, C, Blank, HM, Tsuchiya, M, Schilling, B, Kaeberlein, M et al.. Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity. Elife. 2020;9 :.
    doi: 10.7554/eLife.53127. PubMed PMID:32432546. .

  2. Bermudez, RM, Wu, PI, Callerame, D, Hammer, S, Hu, JC, Polymenis, M et al.. Phenotypic Associations Among Cell Cycle Genes in Saccharomyces cerevisiae. G3 (Bethesda). 2020; :.
    doi: 10.1534/g3.120.401350. PubMed PMID:32376676. .

  3. Blank, HM, Papoulas, O, Maitra, N, Garge, R, Kennedy, BK, Schilling, B et al.. Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism. Mol. Biol. Cell. 2020;31 (10):1069-1084.
    doi: 10.1091/mbc.E19-12-0708. PubMed PMID:32129706. .

  4. Maitra, N, Anandhakumar, J, Blank, HM, Kaplan, CD, Polymenis, M. Perturbations of Transcription and Gene Expression-Associated Processes Alter Distribution of Cell Size Values in Saccharomyces cerevisiae. G3 (Bethesda). 2019;9 (1):239-250.
    doi: 10.1534/g3.118.200854. PubMed PMID:30463882. PubMed Central PMC6325893.

  5. Blank, HM, Callahan, M, Pistikopoulos, IPE, Polymenis, AO, Polymenis, M. Scaling of G1 Duration with Population Doubling Time by a Cyclin in Saccharomyces cerevisiae. Genetics. 2018;210 (3):895-906.
    doi: 10.1534/genetics.118.301507. PubMed PMID:30150288. PubMed Central PMC6218239.

  6. Huang, J, Mousley, CJ, Dacquay, L, Maitra, N, Drin, G, He, C et al.. A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems. Dev. Cell. 2018;44 (3):378-391.e5.
    doi: 10.1016/j.devcel.2017.12.026. PubMed PMID:29396115. PubMed Central PMC6444186.

  7. Polymenis, M. Proteins associated with the doubling time of the NCI-60 cancer cell lines. Cell Div. 2017;12 :6.
    doi: 10.1186/s13008-017-0032-y. PubMed PMID:28855958. PubMed Central PMC5574231.

  8. Polymenis, M, Kennedy, BK. Unbalanced Growth, Senescence and Aging. Adv. Exp. Med. Biol. 2017;1002 :189-208.
    doi: 10.1007/978-3-319-57127-0_8. PubMed PMID:28600787. PubMed Central PMC6345385.

  9. Aramayo, R, Polymenis, M. Ribosome profiling the cell cycle: lessons and challenges. Curr. Genet. 2017;63 (6):959-964.
    doi: 10.1007/s00294-017-0698-3. PubMed PMID:28451847. PubMed Central PMC5790165.

  10. Blank, HM, Maitra, N, Polymenis, M. Lipid biosynthesis: When the cell cycle meets protein synthesis? Cell Cycle. 2017;16 (10):905-906.
    doi: 10.1080/15384101.2017.1312851. PubMed PMID:28418768. PubMed Central PMC5462083.

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