- David Peterson
- Emeritus Professor
- 332 BioBio
- Graduate Education
- A.B. Pomona College (1972)
- Ph.D. Harvard University (1978)
- Postdoc. University of California, San Francisco (1978-81)
- Joined Texas A&M in 1981
We are interested in the molecular mechanisms of transcriptional regulation in mammalian cells. Many of our experiments have focused on the transcription of the proviral genome of the retrovirus mouse mammary tumor virus, which is subject to both positive and negative control. A number of cellular proteins that are important for viral transcription have been identified, and we would like to define the precise roles of these proteins in establishing correct levels of viral gene expression. We are also exploring some specific questions related to the general mechanism of transcription initiation by RNA polymerase II and the biochemical details of transcriptional regulation. In particular, we are developing assays to directly assess effects of transcriptional regulatory proteins on discrete steps in the initiation process, including transcription complex assembly, separation of the two strands of template DNA at the initiation site, and promoter clearance by the polymerase as it begins RNA synthesis.
Kaster, BC, Knippa, KC, Kaplan, CD, Peterson, DO. RNA Polymerase II Trigger Loop Mobility: INDIRECT EFFECTS OF Rpb9. J. Biol. Chem. 2016;291 (28):14883-95.
Knippa, K, Peterson, DO. Fidelity of RNA polymerase II transcription: Role of Rpb9 [corrected] in error detection and proofreading. Biochemistry. 2013;52 (44):7807-17.
Chen, X, Zhang, B, Harmon, PM, Schaffner, W, Peterson, DO, Giedroc, DP et al.. A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. J. Biol. Chem. 2004;279 (6):4515-22.
Fee, BE, Steinke, JW, Pierce, J, Peterson, DO. Initiation site binding protein and the initiator-like promoter element of mouse mammary tumor virus. Virology. 2002;302 (1):185-94.
Steinke, JW, Kopytek, SJ, Peterson, DO. Discrete promoter elements affect specific properties of RNA polymerase II transcription complexes. Nucleic Acids Res. 2000;28 (14):2726-35.
Kang, CJ, Peterson, DO. Identification of a protein that recognizes a distal negative regulatory element within the mouse mammary tumor virus long terminal repeat. Virology. 1999;264 (1):211-9.
Bral, CM, Steinke, JW, Kang, CJ, Peterson, DO. RNA polymerase II transcription complex assembly in nuclear extracts. Gene Expr. 1998;7 (3):191-204.
Kopytek, SJ, Peterson, DO. ATP-mediated activation of RNA polymerase II transcription complexes. Gene Expr. 1998;7 (2):75-86.
Kim, MH, Peterson, DO. Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter. J. Biol. Chem. 1995;270 (46):27823-8.
Kim, MH, Peterson, DO. Stimulation of basal transcription from the mouse mammary tumor virus promoter by Oct proteins. J. Virol. 1995;69 (8):4717-26.