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David Peterson

Peterson, David
David Peterson
Emeritus Professor
332 BioBio
Graduate Education
A.B. Pomona College (1972)
Ph.D. Harvard University (1978)
Postdoc. University of California, San Francisco (1978-81)
Joined Texas A&M in 1981

Eukaryotic Transcription

We are interested in the molecular mechanisms of transcriptional regulation in mammalian cells. Many of our experiments have focused on the transcription of the proviral genome of the retrovirus mouse mammary tumor virus, which is subject to both positive and negative control. A number of cellular proteins that are important for viral transcription have been identified, and we would like to define the precise roles of these proteins in establishing correct levels of viral gene expression. We are also exploring some specific questions related to the general mechanism of transcription initiation by RNA polymerase II and the biochemical details of transcriptional regulation. In particular, we are developing assays to directly assess effects of transcriptional regulatory proteins on discrete steps in the initiation process, including transcription complex assembly, separation of the two strands of template DNA at the initiation site, and promoter clearance by the polymerase as it begins RNA synthesis.

Recent Publications

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  1. Kaster, BC, Knippa, KC, Kaplan, CD, Peterson, DO. RNA Polymerase II Trigger Loop Mobility: INDIRECT EFFECTS OF Rpb9. J. Biol. Chem. 2016;291 (28):14883-95.
    doi: 10.1074/jbc.M116.714394. PubMed PMID:27226557. PubMed Central PMC4938204.

  2. Knippa, K, Peterson, DO. Fidelity of RNA polymerase II transcription: Role of Rpb9 [corrected] in error detection and proofreading. Biochemistry. 2013;52 (44):7807-17.
    doi: 10.1021/bi4009566. PubMed PMID:24099331. .

  3. Chen, X, Zhang, B, Harmon, PM, Schaffner, W, Peterson, DO, Giedroc, DP et al.. A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. J. Biol. Chem. 2004;279 (6):4515-22.
    doi: 10.1074/jbc.M308924200. PubMed PMID:14610091. .

  4. Fee, BE, Steinke, JW, Pierce, J, Peterson, DO. Initiation site binding protein and the initiator-like promoter element of mouse mammary tumor virus. Virology. 2002;302 (1):185-94.
    doi: 10.1006/viro.2002.1603. PubMed PMID:12429527. .

  5. Steinke, JW, Kopytek, SJ, Peterson, DO. Discrete promoter elements affect specific properties of RNA polymerase II transcription complexes. Nucleic Acids Res. 2000;28 (14):2726-35.
    doi: 10.1093/nar/28.14.2726. PubMed PMID:10908329. PubMed Central PMC102648.

  6. Kang, CJ, Peterson, DO. Identification of a protein that recognizes a distal negative regulatory element within the mouse mammary tumor virus long terminal repeat. Virology. 1999;264 (1):211-9.
    doi: 10.1006/viro.1999.9969. PubMed PMID:10544147. .

  7. Bral, CM, Steinke, JW, Kang, CJ, Peterson, DO. RNA polymerase II transcription complex assembly in nuclear extracts. Gene Expr. 1998;7 (3):191-204.
    . PubMed PMID:9840811. PubMed Central PMC6151951.

  8. Kopytek, SJ, Peterson, DO. ATP-mediated activation of RNA polymerase II transcription complexes. Gene Expr. 1998;7 (2):75-86.
    . PubMed PMID:9699480. PubMed Central PMC6190198.

  9. Kim, MH, Peterson, DO. Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter. J. Biol. Chem. 1995;270 (46):27823-8.
    . PubMed PMID:7499253. .

  10. Kim, MH, Peterson, DO. Stimulation of basal transcription from the mouse mammary tumor virus promoter by Oct proteins. J. Virol. 1995;69 (8):4717-26.
    . PubMed PMID:7609037. PubMed Central PMC189278.

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