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Jean-Philippe Pellois

Pellois, Jean-Philippe
Jean-Philippe Pellois
BioBio / Room 438A
Graduate Education
M.Sc. Ecole Supérieure de Chimie Physique Electronique de Lyon (1999)
Ph.D. University of Houston (2002)
Postdoc. The Rockefeller University (2002-2006)
Joined Texas A&M in 2006

Protein Chemistry and Cell Biology

Our goal is to determine how proteins function in space and time in the context of complex cellular networks. We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics. In particular, we use semi-synthetic light-activatable proteins as biophysical probes to investigate protein mechanisms inside living cells. Areas of interest include the important but poorly understood process of protein S-acylation, signal transduction, and protein trafficking.

Recent Publications

  1. Najjar, K, Erazo-Oliveras, A, Mosior, JW, Whitlock, MJ, Rostane, I, Cinclair, JM et al.. Unlocking Endosomal Entrapment with Supercharged Arginine-Rich Peptides. Bioconjug. Chem. 2017; :.
    doi: 10.1021/acs.bioconjchem.7b00560. PubMed PMID:29065262. .

  2. Libardo, MDJ, Wang, TY, Pellois, JP, Angeles-Boza, AM. How Does Membrane Oxidation Affect Cell Delivery and Cell Killing? Trends Biotechnol. 2017;35 (8):686-690.
    doi: 10.1016/j.tibtech.2017.03.015. PubMed PMID:28460718. PubMed Central PMC5522782.

  3. Wang, TY, Libardo, MDJ, Angeles-Boza, AM, Pellois, JP. Membrane Oxidation in Cell Delivery and Cell Killing Applications. ACS Chem. Biol. 2017;12 (5):1170-1182.
    doi: 10.1021/acschembio.7b00237. PubMed PMID:28355059. .

  4. Najjar, K, Erazo-Oliveras, A, Brock, DJ, Wang, TY, Pellois, JP. An l- to d-Amino Acid Conversion in an Endosomolytic Analog of the Cell-penetrating Peptide TAT Influences Proteolytic Stability, Endocytic Uptake, and Endosomal Escape. J. Biol. Chem. 2017;292 (3):847-861.
    doi: 10.1074/jbc.M116.759837. PubMed PMID:27923812. PubMed Central PMC5247658.

  5. Wang, TY, Pellois, JP. Peptide translocation through the plasma membrane of human cells: Can oxidative stress be exploited to gain better intracellular access? Commun Integr Biol. ;9 (4):e1205771.
    doi: 10.1080/19420889.2016.1205771. PubMed PMID:27574543. PubMed Central PMC4988429.

  6. Robison, AD, Sun, S, Poyton, MF, Johnson, GA, Pellois, JP, Jungwirth, P et al.. Polyarginine Interacts More Strongly and Cooperatively than Polylysine with Phospholipid Bilayers. J Phys Chem B. 2016;120 (35):9287-96.
    doi: 10.1021/acs.jpcb.6b05604. PubMed PMID:27571288. .

  7. Erazo-Oliveras, A, Najjar, K, Truong, D, Wang, TY, Brock, DJ, Prater, AR et al.. The Late Endosome and Its Lipid BMP Act as Gateways for Efficient Cytosolic Access of the Delivery Agent dfTAT and Its Macromolecular Cargos. Cell Chem Biol. 2016;23 (5):598-607.
    doi: 10.1016/j.chembiol.2016.03.016. PubMed PMID:27161484. PubMed Central PMC4874899.

  8. Wang, TY, Sun, Y, Muthukrishnan, N, Erazo-Oliveras, A, Najjar, K, Pellois, JP et al.. Membrane Oxidation Enables the Cytosolic Entry of Polyarginine Cell-penetrating Peptides. J. Biol. Chem. 2016;291 (15):7902-14.
    doi: 10.1074/jbc.M115.711564. PubMed PMID:26888085. PubMed Central PMC4824998.

  9. Najjar, K, Erazo-Oliveras, A, Pellois, JP. Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT. J Vis Exp. 2015; (103):.
    doi: 10.3791/53175. PubMed PMID:26382730. PubMed Central PMC4692585.

  10. Li, Z, David, A, Albani, BA, Pellois, JP, Turro, C, Dunbar, KR et al.. Optimizing the electronic properties of photoactive anticancer oxypyridine-bridged dirhodium(II,II) complexes. J. Am. Chem. Soc. 2014;136 (49):17058-70.
    doi: 10.1021/ja5078359. PubMed PMID:25437146. .

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