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Jean-Philippe Pellois

Pellois, Jean-Philippe
Jean-Philippe Pellois
BioBio / Room 438A
Graduate Education
M.Sc. Ecole Supérieure de Chimie Physique Electronique de Lyon (1999)
Ph.D. University of Houston (2002)
Postdoc. The Rockefeller University (2002-2006)
Joined Texas A&M in 2006

Protein Chemistry and Cell Biology

Our goal is to determine how proteins function in space and time in the context of complex cellular networks. We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics. In particular, we use semi-synthetic light-activatable proteins as biophysical probes to investigate protein mechanisms inside living cells. Areas of interest include the important but poorly understood process of protein S-acylation, signal transduction, and protein trafficking.

Recent Publications

  1. Brock, DJ, Kondow-McConaghy, HM, Hager, EC, Pellois, JP. Endosomal Escape and Cytosolic Penetration of Macromolecules Mediated by Synthetic Delivery Agents. Bioconjug. Chem. 2019;30 (2):293-304.
    doi: 10.1021/acs.bioconjchem.8b00799. PubMed PMID:30462487. .

  2. Fang, Y, Lian, X, Huang, Y, Fu, G, Xiao, Z, Wang, Q et al.. Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy. Small. 2018;14 (47):e1802709.
    doi: 10.1002/smll.201802709. PubMed PMID:30222252. .

  3. Allen, JK, Brock, DJ, Kondow-McConaghy, HM, Pellois, JP. Efficient Delivery of Macromolecules into Human Cells by Improving the Endosomal Escape Activity of Cell-Penetrating Peptides: Lessons Learned from dfTAT and its Analogs. Biomolecules. 2018;8 (3):.
    doi: 10.3390/biom8030050. PubMed PMID:29997347. PubMed Central PMC6165022.

  4. Brock, DJ, Kustigian, L, Jiang, M, Graham, K, Wang, TY, Erazo-Oliveras, A et al.. Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides. Traffic. 2018;19 (6):421-435.
    doi: 10.1111/tra.12566. PubMed PMID:29582528. PubMed Central PMC5948172.

  5. Lian, X, Huang, Y, Zhu, Y, Fang, Y, Zhao, R, Joseph, E et al.. Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy. Angew. Chem. Int. Ed. Engl. 2018;57 (20):5725-5730.
    doi: 10.1002/anie.201801378. PubMed PMID:29536600. .

  6. Stubbendieck, RM, Brock, DJ, Pellois, JP, Gill, JJ, Straight, PD. Linearmycins are lytic membrane-targeting antibiotics. J. Antibiot. 2018;71 (3):372-381.
    doi: 10.1038/s41429-017-0005-z. PubMed PMID:29348524. .

  7. Lian, X, Erazo-Oliveras, A, Pellois, JP, Zhou, HC. High efficiency and long-term intracellular activity of an enzymatic nanofactory based on metal-organic frameworks. Nat Commun. 2017;8 (1):2075.
    doi: 10.1038/s41467-017-02103-0. PubMed PMID:29234027. PubMed Central PMC5727123.

  8. Najjar, K, Erazo-Oliveras, A, Mosior, JW, Whitlock, MJ, Rostane, I, Cinclair, JM et al.. Unlocking Endosomal Entrapment with Supercharged Arginine-Rich Peptides. Bioconjug. Chem. 2017;28 (12):2932-2941.
    doi: 10.1021/acs.bioconjchem.7b00560. PubMed PMID:29065262. PubMed Central PMC5905407.

  9. Libardo, MDJ, Wang, TY, Pellois, JP, Angeles-Boza, AM. How Does Membrane Oxidation Affect Cell Delivery and Cell Killing? Trends Biotechnol. 2017;35 (8):686-690.
    doi: 10.1016/j.tibtech.2017.03.015. PubMed PMID:28460718. PubMed Central PMC5522782.

  10. Wang, TY, Libardo, MDJ, Angeles-Boza, AM, Pellois, JP. Membrane Oxidation in Cell Delivery and Cell Killing Applications. ACS Chem. Biol. 2017;12 (5):1170-1182.
    doi: 10.1021/acschembio.7b00237. PubMed PMID:28355059. PubMed Central PMC5905413.

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