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Magnus Höök

Höök, Magnus
Magnus Höök
Professor of Biochemistry and Biophysics, of the IBT-Houston, and of Veterinary Anatomy and Public Health Director, Center for Extracellular Matrix Biology
Undergraduate Education
B.S. University of Uppsala, Sweden (1971)
Graduate Education
Ph.D. University of Uppsala, Sweden (1974)
Joined Texas A&M in 1992

Microbial Pathogenesis / Virulence Factors / Cell Adhesion

The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.

Recent Publications

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  1. Stampas, A, Pedroza, C, Bush, JN, Ferguson, AR, Kramer, JLK, Hook, M et al.. The first 24 h: opioid administration in people with spinal cord injury and neurologic recovery. Spinal Cord. 2020; :.
    doi: 10.1038/s41393-020-0483-x. PubMed PMID:32461572. .

  2. Arora, S, Li, X, Hillhouse, A, Konganti, K, Little, SV, Lawhon, SD et al.. Staphylococcus epidermidis MSCRAMM SesJ Is Encoded in Composite Islands. mBio. 2020;11 (1):.
    doi: 10.1128/mBio.02911-19. PubMed PMID:32071265. PubMed Central PMC7029136.

  3. Pickering, AC, Vitry, P, Prystopiuk, V, Garcia, B, Höök, M, Schoenebeck, J et al.. Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion. PLoS Pathog. 2019;15 (6):e1007816.
    doi: 10.1371/journal.ppat.1007816. PubMed PMID:31216354. PubMed Central PMC6602291.

  4. Thomas, S, Liu, W, Arora, S, Ganesh, V, Ko, YP, Höök, M et al.. The Complex Fibrinogen Interactions of the Staphylococcus aureus Coagulases. Front Cell Infect Microbiol. 2019;9 :106.
    doi: 10.3389/fcimb.2019.00106. PubMed PMID:31041195. PubMed Central PMC6476931.

  5. Post, A, Isgandarova, S, Martinez-Moczygemba, M, Hahn, M, Russell, B, Hook, M et al.. Elucidation of Endothelial Cell Hemostatic Regulation with Integrin-Targeting Hydrogels. Ann Biomed Eng. 2019;47 (3):866-877.
    doi: 10.1007/s10439-018-02194-w. PubMed PMID:30607644. .

  6. Becerra-Bayona, SM, Guiza-Arguello, VR, Russell, B, Höök, M, Hahn, MS. Influence of collagen-based integrin α1 and α2 mediated signaling on human mesenchymal stem cell osteogenesis in three dimensional contexts. J Biomed Mater Res A. 2018;106 (10):2594-2604.
    doi: 10.1002/jbm.a.36451. PubMed PMID:29761640. PubMed Central PMC7147932.

  7. Casillas-Ituarte, NN, Cruz, CHB, Lins, RD, DiBartola, AC, Howard, J, Liang, X et al.. Amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation. J. Biol. Chem. 2017;292 (21):8797-8810.
    doi: 10.1074/jbc.M117.786012. PubMed PMID:28400484. PubMed Central PMC5448106.

  8. Munoz-Pinto, DJ, Erndt-Marino, JD, Becerra-Bayona, SM, Guiza-Arguello, VR, Samavedi, S, Malmut, S et al.. Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels. J Biomed Mater Res A. 2017;105 (6):1712-1724.
    doi: 10.1002/jbm.a.36045. PubMed PMID:28218444. PubMed Central PMC7147939.

  9. Ganesh, VK, Liang, X, Geoghegan, JA, Cohen, ALV, Venugopalan, N, Foster, TJ et al.. Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody. EBioMedicine. 2016;13 :328-338.
    doi: 10.1016/j.ebiom.2016.09.027. PubMed PMID:27789272. PubMed Central PMC5264652.

  10. Liang, X, Garcia, BL, Visai, L, Prabhakaran, S, Meenan, NA, Potts, JR et al.. Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs. PLoS ONE. 2016;11 (7):e0159118.
    doi: 10.1371/journal.pone.0159118. PubMed PMID:27434228. PubMed Central PMC4951027.

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