- Undergraduate Education
- B.S. China Agricultural University (1993)
- Graduate Education
- M.S. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (1998)
- Ph.D. Kansas State University (2003)
- Postdoc. Massachusetts General Hospital and Harvard Medical School (2003-2008)
- Joined Texas A&M in 2009
- NSF CAREER Award 2013
Signal Transduction in Plant Innate Immunity
Plants and animals, under constant attack by microbes, have evolved sophisticated immune systems to defend against infections. In turn, successful pathogens have developed elegant virulence strategies to suppress host immunity. Long-standing association between hosts and microbes has resulted in both acquiring specific adaptations which maximize their own survival and productivity.
Our laboratory is interested in elucidating novel plant immune signaling pathways as well as studying the myriad actions of pathogen virulence factors that intercept host immune responses. In order to provide a complete view of host-microbe interactions, we are using cellular, functional genomic, genetic, biochemical and bioinformatic approaches. In addition, plant immunity is inextricably linked with plant development and environmental stresses. We are also interested in understanding the signaling crosstalk that orchestrates plant responses to different extrinsic and intrinsic signals. Ultimately, knowledge gained from studying model plants, such as Arabidopsis, will be applied to improve crop plants for resistance against different biotic and abiotic stresses.
Hou, S, Jamieson, P, He, P. The cloak, dagger, and shield: proteases in plant-pathogen interactions. Biochem. J. 2018;475 (15):2491-2509.
Xiong, C, Luo, D, Lin, A, Zhang, C, Shan, L, He, P et al.. A tomato B-box protein SlBBX20 modulates carotenoid biosynthesis by directly activating PHYTOENE SYNTHASE 1, and is targeted for 26S proteasome-mediated degradation. New Phytol. 2019;221 (1):279-294.
Jamieson, PA, Shan, L, He, P. Plant cell surface molecular cypher: Receptor-like proteins and their roles in immunity and development. Plant Sci. 2018;274 :242-251.
Lal, NK, Nagalakshmi, U, Hurlburt, NK, Flores, R, Bak, A, Sone, P et al.. The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity. Cell Host Microbe. 2018;23 (4):485-497.e5.
Shan, L, He, P. Pipped at the Post: Pipecolic Acid Derivative Identified as SAR Regulator. Cell. 2018;173 (2):286-287.
Zhou, J, Liu, D, Wang, P, Ma, X, Lin, W, Chen, S et al.. Regulation of Arabidopsis brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (8):E1906-E1915.
Mang, H, Feng, B, Hu, Z, Boisson-Dernier, A, Franck, CM, Meng, X et al.. Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases. Plant Cell. 2017;29 (12):3140-3156.
Li, F, Li, M, Wang, P, Cox, KL Jr, Duan, L, Dever, JK et al.. Regulation of cotton (Gossypium hirsutum) drought responses by mitogen-activated protein (MAP) kinase cascade-mediated phosphorylation of GhWRKY59. New Phytol. 2017;215 (4):1462-1475.
Cox, KL, Meng, F, Wilkins, KE, Li, F, Wang, P, Booher, NJ et al.. TAL effector driven induction of a SWEET gene confers susceptibility to bacterial blight of cotton. Nat Commun. 2017;8 :15588.
Yu, X, Feng, B, He, P, Shan, L. From Chaos to Harmony: Responses and Signaling upon Microbial Pattern Recognition. Annu Rev Phytopathol. 2017;55 :109-137.