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Vishal Gohil

Gohil, Vishal
Vishal Gohil
Assistant Professor
Office:
ILSB, Room 2146A
Email:
Phone:
979-847-6138
http://www.gohillab.com
Undergraduate Education
B.Sc. Mohan Lal Sukhadia University, India (1995)
Graduate Education
M.Sc. Maharaja Sayajirao University of Baroda, India (1997)
Ph.D. Wayne State University, Detroit (2005)
Postdoc. Massachusetts General Hospital, Boston (2005-2008)
Instructor in Medicine, Harvard Medical School, Boston (2008-2011)
Joined Texas A&M in 2012

Mitochondrial Respiratory Chain Biogenesis

Despite the fundamental role of the mitochondrion in cellular energy production and its involvement in numerous human diseases, we still do not know the function of nearly 20% of the known mitochondrial proteins. My laboratory applies genomic, genetic, and biochemical tools to uncover the role of these uncharacterized proteins in the mitochondrial respiratory chain (MRC) biogenesis. MRC is the main site of cellular respiration and energy production and since the core components of the MRC are evolutionarily conserved, we reason that the assembly factors required to build the MRC should also be conserved. Therefore, we utilize multiple models systems, including yeast, zebrafish, and human cell lines, to determine the role of these conserved, uncharacterized mitochondrial proteins in bioenergetics, organismal development, and human disease pathogenesis.

Another poorly understood aspect of the mitochondrial energy metabolism is the role of phospholipids in maintaining the structural and functional integrity of the MRC. Although it is well known that the MRC is localized in the inner mitochondrial membrane, how the unique lipid milieu of the mitochondrial membrane influences the assembly and activity of the MRC is not fully understood. We have constructed yeast mutants with defined mitochondrial phospholipid compositions to systematically determine each lipid’s role in MRC assembly and activity. Ultimately, defining the roles of mitochondrial proteins and phospholipids will allow us to develop better diagnostic and therapeutic options for human disorders resulting from mitochondrial dysfunction.

Recent Publications

  1. Baker, CD, Basu Ball, W, Pryce, EN, Gohil, VM. Specific requirements of nonbilayer phospholipids in mitochondrial respiratory chain function and formation. Mol. Biol. Cell. 2016;27 (14):2161-71.
    doi: 10.1091/mbc.E15-12-0865. PubMed PMID:27226479. PubMed Central PMC4945136.

  2. Tomar, D, Dong, Z, Shanmughapriya, S, Koch, DA, Thomas, T, Hoffman, NE et al.. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Cell Rep. 2016;15 (8):1673-85.
    doi: 10.1016/j.celrep.2016.04.050. PubMed PMID:27184846. PubMed Central PMC4880542.

  3. Ghosh, A, Pratt, AT, Soma, S, Theriault, SG, Griffin, AT, Trivedi, PP et al.. Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis. Hum. Mol. Genet. 2016;25 (4):660-71.
    doi: 10.1093/hmg/ddv503. PubMed PMID:26669719. PubMed Central PMC4743686.

  4. Kishi, S, Campanholle, G, Gohil, VM, Perocchi, F, Brooks, CR, Morizane, R et al.. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015;2 (9):1090-101.
    doi: 10.1016/j.ebiom.2015.07.035. PubMed PMID:26501107. PubMed Central PMC4588407.

  5. Ghosh, A, Trivedi, PP, Timbalia, SA, Griffin, AT, Rahn, JJ, Chan, SS et al.. Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Hum. Mol. Genet. 2014;23 (13):3596-606.
    doi: 10.1093/hmg/ddu069. PubMed PMID:24549041. PubMed Central PMC4049311.

  6. Jhurry, ND, Chakrabarti, M, McCormick, SP, Gohil, VM, Lindahl, PA. Mössbauer study and modeling of iron import and trafficking in human jurkat cells. Biochemistry. 2013;52 (45):7926-42.
    doi: 10.1021/bi401015t. PubMed PMID:24180611. PubMed Central PMC3979524.

  7. Gohil, VM, Zhu, L, Baker, CD, Cracan, V, Yaseen, A, Jain, M et al.. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J. Biol. Chem. 2013;288 (49):35387-95.
    doi: 10.1074/jbc.M113.489237. PubMed PMID:24142790. PubMed Central PMC3853286.

  8. Patil, VA, Fox, JL, Gohil, VM, Winge, DR, Greenberg, ML. Loss of cardiolipin leads to perturbation of mitochondrial and cellular iron homeostasis. J. Biol. Chem. 2013;288 (3):1696-705.
    doi: 10.1074/jbc.M112.428938. PubMed PMID:23192348. PubMed Central PMC3548480.

  9. Gohil, VM, Offner, N, Walker, JA, Sheth, SA, Fossale, E, Gusella, JF et al.. Meclizine is neuroprotective in models of Huntington's disease. Hum. Mol. Genet. 2011;20 (2):294-300.
    doi: 10.1093/hmg/ddq464. PubMed PMID:20977989. PubMed Central PMC3005902.

  10. Perocchi, F, Gohil, VM, Girgis, HS, Bao, XR, McCombs, JE, Palmer, AE et al.. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 2010;467 (7313):291-6.
    doi: 10.1038/nature09358. PubMed PMID:20693986. PubMed Central PMC2977980.

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