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Vishal Gohil

Gohil, Vishal
Vishal Gohil
Assistant Professor
ILSB, Room 2146A
Undergraduate Education
B.Sc. Mohan Lal Sukhadia University, India (1995)
Graduate Education
M.Sc. Maharaja Sayajirao University of Baroda, India (1997)
Ph.D. Wayne State University, Detroit (2005)
Postdoc. Massachusetts General Hospital, Boston (2005-2008)
Instructor in Medicine, Harvard Medical School, Boston (2008-2011)
Joined Texas A&M in 2012

Mitochondrial Biogenesis and Energy Metabolism

Our long-term research objective is to understand the biogenesis of mitochondrial respiratory chain (MRC) complexes. The MRC is present in the inner mitochondrial membrane and is the main site for cellular respiration and energy production. It consists of five multi-protein complexes composed of ~90 subunits that assemble into supra-molecular structures called supercomplexes. MRC biogenesis is a complex, multi-step process facilitated by hundreds of uncharacterized factors. Despite insights gained through decades of research on mitochondrial bioenergetics, our understanding of MRC biogenesis is incomplete, and many fundamental questions remain unanswered. For example, what factors are required for the formation and stabilization of MRC complexes and supercomplexes? What role does the lipid milieu play in MRC complex assembly? We have two ongoing projects that will address these important questions using the tools of genomics, genetics, and biochemistry in human cells and the yeast Saccharomyces cerevisiae.

Recent Publications

  1. Baker, CD, Basu Ball, W, Pryce, EN, Gohil, VM. Specific requirements of nonbilayer phospholipids in mitochondrial respiratory chain function and formation. Mol. Biol. Cell. 2016;27 (14):2161-71.
    doi: 10.1091/mbc.E15-12-0865. PubMed PMID:27226479. PubMed Central PMC4945136.

  2. Tomar, D, Dong, Z, Shanmughapriya, S, Koch, DA, Thomas, T, Hoffman, NE et al.. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Cell Rep. 2016;15 (8):1673-85.
    doi: 10.1016/j.celrep.2016.04.050. PubMed PMID:27184846. PubMed Central PMC4880542.

  3. Ghosh, A, Pratt, AT, Soma, S, Theriault, SG, Griffin, AT, Trivedi, PP et al.. Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis. Hum. Mol. Genet. 2016;25 (4):660-71.
    doi: 10.1093/hmg/ddv503. PubMed PMID:26669719. PubMed Central PMC4743686.

  4. Kishi, S, Campanholle, G, Gohil, VM, Perocchi, F, Brooks, CR, Morizane, R et al.. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015;2 (9):1090-101.
    doi: 10.1016/j.ebiom.2015.07.035. PubMed PMID:26501107. PubMed Central PMC4588407.

  5. Ghosh, A, Trivedi, PP, Timbalia, SA, Griffin, AT, Rahn, JJ, Chan, SS et al.. Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Hum. Mol. Genet. 2014;23 (13):3596-606.
    doi: 10.1093/hmg/ddu069. PubMed PMID:24549041. PubMed Central PMC4049311.

  6. Jhurry, ND, Chakrabarti, M, McCormick, SP, Gohil, VM, Lindahl, PA. Mössbauer study and modeling of iron import and trafficking in human jurkat cells. Biochemistry. 2013;52 (45):7926-42.
    doi: 10.1021/bi401015t. PubMed PMID:24180611. PubMed Central PMC3979524.

  7. Gohil, VM, Zhu, L, Baker, CD, Cracan, V, Yaseen, A, Jain, M et al.. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J. Biol. Chem. 2013;288 (49):35387-95.
    doi: 10.1074/jbc.M113.489237. PubMed PMID:24142790. PubMed Central PMC3853286.

  8. Patil, VA, Fox, JL, Gohil, VM, Winge, DR, Greenberg, ML. Loss of cardiolipin leads to perturbation of mitochondrial and cellular iron homeostasis. J. Biol. Chem. 2013;288 (3):1696-705.
    doi: 10.1074/jbc.M112.428938. PubMed PMID:23192348. PubMed Central PMC3548480.

  9. Gohil, VM, Offner, N, Walker, JA, Sheth, SA, Fossale, E, Gusella, JF et al.. Meclizine is neuroprotective in models of Huntington's disease. Hum. Mol. Genet. 2011;20 (2):294-300.
    doi: 10.1093/hmg/ddq464. PubMed PMID:20977989. PubMed Central PMC3005902.

  10. Perocchi, F, Gohil, VM, Girgis, HS, Bao, XR, McCombs, JE, Palmer, AE et al.. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 2010;467 (7313):291-6.
    doi: 10.1038/nature09358. PubMed PMID:20693986. PubMed Central PMC2977980.

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