- Suma Datta
- Professor of Biochemistry and Biophysics and of Biology; Executive Director of Honors and Undergraduate Research at Texas A&M
- Undergraduate Education
- B.Sc. University of Michigan (1980)
- Graduate Education
- Ph.D. University of California, San Diego (1987)
- Postdoc. Yale University (1987-92)
- Joined Texas A&M in 1993
Developmental Control of Stem Cell Cycle Proliferation
We are currently investigating how organismal level cues regulate the onset of stem cell division during development. Our primary system is the neuroblasts in the brain of the fruit fly, Drosophila melanogaster. The trol gene of Drosophila encodes the fly homolog of the mammalian heparan sulfate glycoprotein, Perlecan. Perlecan is found in mice, humans, and C. elegans, and is widely known as a co-receptor for the growth factor FGF. We have shown that Trol, the Drosophila Perlecan homolog, is required for signaling by FGF. Furthermore, we have demonstrated that Trol is also a likely candidate for the Hedgehog co-receptor. Hedgehogs are peptide growth factors which are conserved in mammals and require heparan sulfate glycoproteins for their movement and long-range signaling; however, until now the identity of the protein core was unknown. Our studies demonstrate genetic interactions between trol and hedgehog or patched mutations (patched is the Hedgehog receptor). Further studies reveal that both FGF and Hedgehog signaling activate stem cell division. Current projects involve determining how Trol stimulates FGF and Hedgehog signaling through genetic, molecular, and biochemical analyses.
Ferguson, BW, Datta, S. Role of heparan sulfate 2-o-sulfotransferase in prostate cancer cell proliferation, invasion, and growth factor signaling. Prostate Cancer. 2011;2011 :893208.
Barrett, A, Krueger, S, Jackson, M, Datta, S. Curable genetic instability of a gal4 transgene in Drosophila. Fly (Austin). ;2 (2):67-73.
Barrett, AL, Krueger, S, Datta, S. Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain. Dev. Biol. 2008;317 (1):234-45.
Lindner, JR, Hillman, PR, Barrett, AL, Jackson, MC, Perry, TL, Park, Y et al.. The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts. BMC Dev. Biol. 2007;7 :121.
Datta, S, Pierce, M, Datta, MW. Perlecan signaling: helping hedgehog stimulate prostate cancer growth. Int. J. Biochem. Cell Biol. 2006;38 (11):1855-61.
Datta, MW, Hernandez, AM, Schlicht, MJ, Kahler, AJ, DeGueme, AM, Dhir, R et al.. Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. Mol. Cancer. 2006;5 :9.
Datta, S, Datta, MW. Sonic Hedgehog signaling in advanced prostate cancer. Cell. Mol. Life Sci. 2006;63 (4):435-48.
Liu, Y, Ahn, JE, Datta, S, Salzman, RA, Moon, J, Huyghues-Despointes, B et al.. Arabidopsis vegetative storage protein is an anti-insect acid phosphatase. Plant Physiol. 2005;139 (3):1545-56.
Sanchez, P, Hernández, AM, Stecca, B, Kahler, AJ, DeGueme, AM, Barrett, A et al.. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc. Natl. Acad. Sci. U.S.A. 2004;101 (34):12561-6.
Park, Y, Ng, C, Datta, S. Induction of string rescues the neuroblast proliferation defect in trol mutant animals. Genesis. 2003;36 (4):187-95.