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Robert Chapkin

Chapkin, Robert
Robert Chapkin
Professor
Office:
CMAT 111
Email:
Phone:
979-845-0419
http://chapkinlab.tamu.edu/
Undergraduate Education
B.Sc. University of Guelph, Canada (1981)
Graduate Education
M.Sc. University of Guelph, Canada (1983)
Ph.D. University of California, Davis (1986)
Postdoc. University of California, Davis School of Medicine (1986-88)
Joined Texas A&M in 1988

Stem cells, membrane biology and chronic disease prevention

Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases. Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation.  Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors.  As part of this endeavor, we are modeling, at the molecular level, the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.  Work in the lab related to intestinal “phenotypic flexibility” falls into four specific areas:

  • Synergistic effects of systemic and lumenal metabolites on intestinal stem cells and differentiated colonocytes.
  • Development of novel noninvasive methodology using exfoliated cells (exfoliome) to monitor host/microbe interactions.
  • Effects of dietary/microbial bioactives on plasma membrane structure (proteolipid clustering) and function.
  • Investigation of the role of dietary and microbial ligands as modifiers of inflammation and colon cancer development.

Recent Publications

  1. Torres-Adorno, AM, Vitrac, H, Qi, Y, Tan, L, Levental, KR, Fan, YY et al.. Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux. Oncogene. 2018; :.
    doi: 10.1038/s41388-018-0569-5. PubMed PMID:30459358. .

  2. Kim, E, Wright, GA, Zoh, RS, Patil, BS, Jayaprakasha, GK, Callaway, ES et al.. Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model. Eur. J. Cancer Prev. 2018; :.
    doi: 10.1097/CEJ.0000000000000465. PubMed PMID:30234553. .

  3. Erazo-Oliveras, A, Fuentes, NR, Wright, RC, Chapkin, RS. Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents. Cancer Metastasis Rev. 2018;37 (2-3):519-544.
    doi: 10.1007/s10555-018-9733-1. PubMed PMID:29860560. PubMed Central PMC6296755.

  4. Fuentes, NR, Mlih, M, Barhoumi, R, Fan, YY, Hardin, P, Steele, TJ et al.. Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition. Cancer Res. 2018;78 (14):3899-3912.
    doi: 10.1158/0008-5472.CAN-18-0324. PubMed PMID:29769200. PubMed Central PMC6050089.

  5. Triff, K, McLean, MW, Callaway, E, Goldsby, J, Ivanov, I, Chapkin, RS et al.. Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model. Int. J. Cancer. 2018;143 (6):1402-1415.
    doi: 10.1002/ijc.31525. PubMed PMID:29659013. PubMed Central PMC6105390.

  6. Jin, UH, Park, H, Li, X, Davidson, LA, Allred, C, Patil, B et al.. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. Toxicol. Sci. 2018;164 (1):205-217.
    doi: 10.1093/toxsci/kfy075. PubMed PMID:29584932. PubMed Central PMC6016704.

  7. Kim, SM, Neuendorff, N, Alaniz, RC, Sun, Y, Chapkin, RS, Earnest, DJ et al.. Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high-fat diet on inflammation and metabolism. FASEB J. 2018;32 (6):3085-3095.
    doi: 10.1096/fj.201700784R. PubMed PMID:29405095. PubMed Central PMC5956251.

  8. Fan, YY, Fuentes, NR, Hou, TY, Barhoumi, R, Li, XC, Deutz, NEP et al.. Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA. Br. J. Nutr. 2018;119 (2):163-175.
    doi: 10.1017/S0007114517003385. PubMed PMID:29249211. PubMed Central PMC5927572.

  9. Whitfield-Cargile, CM, Cohen, ND, He, K, Ivanov, I, Goldsby, JS, Chamoun-Emanuelli, A et al.. The non-invasive exfoliated transcriptome (exfoliome) reflects the tissue-level transcriptome in a mouse model of NSAID enteropathy. Sci Rep. 2017;7 (1):14687.
    doi: 10.1038/s41598-017-13999-5. PubMed PMID:29089621. PubMed Central PMC5665873.

  10. Wei, Q, Lee, JH, Wang, H, Bongmba, OYN, Wu, CS, Pradhan, G et al.. Adiponectin is required for maintaining normal body temperature in a cold environment. BMC Physiol. 2017;17 (1):8.
    doi: 10.1186/s12899-017-0034-7. PubMed PMID:29058611. PubMed Central PMC5651620.

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