- Undergraduate Education
- B.Sc. University of Guelph, Canada (1981)
- Graduate Education
- M.Sc. University of Guelph, Canada (1983)
- Ph.D. University of California, Davis (1986)
- Postdoc. University of California, Davis School of Medicine (1986-88)
- Joined Texas A&M in 1988
Stem cells, membrane biology and chronic disease prevention
Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases. Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling, at the molecular level, the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche. Work in the lab related to intestinal “phenotypic flexibility” falls into four specific areas:
- Synergistic effects of systemic and lumenal metabolites on intestinal stem cells and differentiated colonocytes.
- Development of novel noninvasive methodology using exfoliated cells (exfoliome) to monitor host/microbe interactions.
- Effects of dietary/microbial bioactives on plasma membrane structure (proteolipid clustering) and function.
- Investigation of the role of dietary and microbial ligands as modifiers of inflammation and colon cancer development.
Salinas, ML, Fuentes, NR, Choate, R, Wright, RC, McMurray, DN, Chapkin, RS et al.. AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity. Biophys. J. 2019; :.
Park, H, Jin, UH, Orr, AA, Echegaray, SP, Davidson, LA, Allred, CD et al.. Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. Chem. Res. Toxicol. 2019; :.
Safe, S, Han, H, Goldsby, J, Mohankumar, K, Chapkin, RS. Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies. Curr Opin Toxicol. ;11-12 :10-20.
Lampe, JW, Kim, E, Levy, L, Davidson, LA, Goldsby, JS, Miles, FL et al.. Colonic mucosal and exfoliome transcriptomic profiling and fecal microbiome response to a flaxseed lignan extract intervention in humans. Am. J. Clin. Nutr. 2019;110 (2):377-390.
Torres-Adorno, AM, Vitrac, H, Qi, Y, Tan, L, Levental, KR, Fan, YY et al.. Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux. Oncogene. 2019;38 (12):2135-2150.
Kim, E, Wright, GA, Zoh, RS, Patil, BS, Jayaprakasha, GK, Callaway, ES et al.. Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model. Eur. J. Cancer Prev. 2019;28 (5):383-389.
Erazo-Oliveras, A, Fuentes, NR, Wright, RC, Chapkin, RS. Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents. Cancer Metastasis Rev. 2018;37 (2-3):519-544.
Fuentes, NR, Mlih, M, Barhoumi, R, Fan, YY, Hardin, P, Steele, TJ et al.. Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition. Cancer Res. 2018;78 (14):3899-3912.
Triff, K, McLean, MW, Callaway, E, Goldsby, J, Ivanov, I, Chapkin, RS et al.. Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model. Int. J. Cancer. 2018;143 (6):1402-1415.
Jin, UH, Park, H, Li, X, Davidson, LA, Allred, C, Patil, B et al.. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. Toxicol. Sci. 2018;164 (1):205-217.