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Robert Chapkin

Chapkin, Robert
Robert Chapkin
CMAT 111
Undergraduate Education
B.Sc. University of Guelph, Canada (1981)
Graduate Education
M.Sc. University of Guelph, Canada (1983)
Ph.D. University of California, Davis (1986)
Postdoc. University of California, Davis School of Medicine (1986-88)
Joined Texas A&M in 1988

Stem cells, membrane biology and chronic disease prevention

Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases. Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation.  Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors.  As part of this endeavor, we are modeling, at the molecular level, the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.  Work in the lab related to intestinal “phenotypic flexibility” falls into four specific areas:

  • Synergistic effects of systemic and lumenal metabolites on intestinal stem cells and differentiated colonocytes.
  • Development of novel noninvasive methodology using exfoliated cells (exfoliome) to monitor host/microbe interactions.
  • Effects of dietary/microbial bioactives on plasma membrane structure (proteolipid clustering) and function.
  • Investigation of the role of dietary and microbial ligands as modifiers of inflammation and colon cancer development.

Recent Publications

  1. Coleman, MC, Whitfield-Cargile, C, Cohen, ND, Goldsby, JL, Davidson, L, Chamoun-Emanuelli, AM et al.. Non-invasive evaluation of the equine gastrointestinal mucosal transcriptome. PLoS ONE. 2020;15 (3):e0229797.
    doi: 10.1371/journal.pone.0229797. PubMed PMID:32176710. PubMed Central PMC7075554.

  2. Levental, KR, Malmberg, E, Symons, JL, Fan, YY, Chapkin, RS, Ernst, R et al.. Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness. Nat Commun. 2020;11 (1):1339.
    doi: 10.1038/s41467-020-15203-1. PubMed PMID:32165635. PubMed Central PMC7067841.

  3. Kuklinski, EJ, Hom, MM, Ying, GS, Lin, MC, Chapkin, RS, Jones, R et al.. Associations Between Systemic Omega-3 Fatty Acid Levels With Moderate-to-Severe Dry Eye Disease Signs and Symptoms at Baseline in the Dry Eye Assessment and Management Study. Eye Contact Lens. 2020; :.
    doi: 10.1097/ICL.0000000000000687. PubMed PMID:32097181. .

  4. Bresalier, RS, Chapkin, RS. Human Microbiome in Health and Disease: The Good, the Bad, and the Bugly. Dig. Dis. Sci. 2020;65 (3):671-673.
    doi: 10.1007/s10620-020-06059-y. PubMed PMID:32076932. .

  5. Chapkin, RS, Navarro, SL, Hullar, MAJ, Lampe, JW. Diet and Gut Microbes Act Coordinately to Enhance Programmed Cell Death and Reduce Colorectal Cancer Risk. Dig. Dis. Sci. 2020;65 (3):840-851.
    doi: 10.1007/s10620-020-06106-8. PubMed PMID:32006211. .

  6. Garcia-Villatoro, EL, DeLuca, JAA, Callaway, ES, Allred, KF, Davidson, LA, Hensel, ME et al.. Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 2020;318 (3):G451-G463.
    doi: 10.1152/ajpgi.00268.2019. PubMed PMID:31905023. PubMed Central PMC7137094.

  7. Wyatt, GL, Crump, LS, Young, CM, Wessells, VM, McQueen, CM, Wall, SW et al.. Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer. Breast Cancer Res. 2019;21 (1):131.
    doi: 10.1186/s13058-019-1224-y. PubMed PMID:31783895. PubMed Central PMC6884910.

  8. Salinas, ML, Fuentes, NR, Choate, R, Wright, RC, McMurray, DN, Chapkin, RS et al.. AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity. Biophys. J. 2020;118 (4):885-897.
    doi: 10.1016/j.bpj.2019.09.009. PubMed PMID:31630812. PubMed Central PMC7036725.

  9. Park, H, Jin, UH, Orr, AA, Echegaray, SP, Davidson, LA, Allred, CD et al.. Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. Chem. Res. Toxicol. 2019;32 (11):2353-2364.
    doi: 10.1021/acs.chemrestox.9b00352. PubMed PMID:31621310. PubMed Central PMC6938648.

  10. Safe, S, Han, H, Goldsby, J, Mohankumar, K, Chapkin, RS. Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies. Curr Opin Toxicol. ;11-12 :10-20.
    doi: 10.1016/j.cotox.2018.11.005. PubMed PMID:31453421. PubMed Central PMC6709982.

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