- Undergraduate Education
- B.Sc. University of Guelph, Canada (1981)
- Graduate Education
- M.Sc. University of Guelph, Canada (1983)
- Ph.D. University of California, Davis (1986)
- Postdoc. University of California, Davis School of Medicine (1986-88)
- Joined Texas A&M in 1988
Stem cells, membrane biology and chronic disease prevention
Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases. Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling, at the molecular level, the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche. Work in the lab related to intestinal “phenotypic flexibility” falls into four specific areas:
- Synergistic effects of systemic and lumenal metabolites on intestinal stem cells and differentiated colonocytes.
- Development of novel noninvasive methodology using exfoliated cells (exfoliome) to monitor host/microbe interactions.
- Effects of dietary/microbial bioactives on plasma membrane structure (proteolipid clustering) and function.
- Investigation of the role of dietary and microbial ligands as modifiers of inflammation and colon cancer development.
Coleman, MC, Whitfield-Cargile, C, Cohen, ND, Goldsby, JL, Davidson, L, Chamoun-Emanuelli, AM et al.. Non-invasive evaluation of the equine gastrointestinal mucosal transcriptome. PLoS ONE. 2020;15 (3):e0229797.
Levental, KR, Malmberg, E, Symons, JL, Fan, YY, Chapkin, RS, Ernst, R et al.. Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness. Nat Commun. 2020;11 (1):1339.
Kuklinski, EJ, Hom, MM, Ying, GS, Lin, MC, Chapkin, RS, Jones, R et al.. Associations Between Systemic Omega-3 Fatty Acid Levels With Moderate-to-Severe Dry Eye Disease Signs and Symptoms at Baseline in the Dry Eye Assessment and Management Study. Eye Contact Lens. 2020; :.
Bresalier, RS, Chapkin, RS. Human Microbiome in Health and Disease: The Good, the Bad, and the Bugly. Dig. Dis. Sci. 2020;65 (3):671-673.
Chapkin, RS, Navarro, SL, Hullar, MAJ, Lampe, JW. Diet and Gut Microbes Act Coordinately to Enhance Programmed Cell Death and Reduce Colorectal Cancer Risk. Dig. Dis. Sci. 2020;65 (3):840-851.
Garcia-Villatoro, EL, DeLuca, JAA, Callaway, ES, Allred, KF, Davidson, LA, Hensel, ME et al.. Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 2020;318 (3):G451-G463.
Wyatt, GL, Crump, LS, Young, CM, Wessells, VM, McQueen, CM, Wall, SW et al.. Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer. Breast Cancer Res. 2019;21 (1):131.
Salinas, ML, Fuentes, NR, Choate, R, Wright, RC, McMurray, DN, Chapkin, RS et al.. AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity. Biophys. J. 2020;118 (4):885-897.
Park, H, Jin, UH, Orr, AA, Echegaray, SP, Davidson, LA, Allred, CD et al.. Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. Chem. Res. Toxicol. 2019;32 (11):2353-2364.
Safe, S, Han, H, Goldsby, J, Mohankumar, K, Chapkin, RS. Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies. Curr Opin Toxicol. ;11-12 :10-20.