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José Alfredo Caro

Caro, José Alfredo
José Alfredo Caro
Research Assistant Professor
NMR 313A

Research Interests

I am fascinated by the challenge of using physical formalisms to describe the heterogeneous systems of biology. I want to bridge the structure-function relationship in proteins by explaining the structural determinants of protein dynamics and conformational plasticity. Lessons from this effort have allowed me to develop a completely novel approach to affinity modulation based around targetable entropic hotspots. Use of this strategy to tune function in systems of high biomedical relevance is the foundation of my research.