{"id":7,"date":"2023-11-29T15:48:50","date_gmt":"2023-11-29T15:48:50","guid":{"rendered":"https:\/\/biochemistry.tamu.edu\/lbsd\/?page_id=7"},"modified":"2025-06-20T15:15:31","modified_gmt":"2025-06-20T15:15:31","slug":"7-2","status":"publish","type":"page","link":"https:\/\/biochemistry.tamu.edu\/lbsd\/","title":{"rendered":"Welcome to the Laboratory for Biomolecular Structure and Dynamics (LBSD)"},"content":{"rendered":"\n
\"\"\/<\/div>
\n

Welcome to the Laboratory for Biomolecular Structure and Dynamics (LBSD)<\/h1>\n<\/div><\/div><\/div>\n\n\n\n
<\/div>\n\n\n\n

Adding a rare new capability, the Department of Biochemistry and Biophysics now houses a leading-edge 300 kV cryo-electron microscope. The award-winning Krios G4 provides unrivaled atomic resolution for single-particle and tomographic cryo-electron microscopy.<\/p>\n\n\n\n

The carefully renovated space for the instrument in the Biochemistry and Biophysics Building was built to minimize vibrations and other interferences. A continuous air exchange system allows for temperature control with minimum change in airflow. The room is also humidity-controlled to reduce ice contamination on the grids during handling.<\/p>\n\n\n\n

In September 2022, technical experts from Thermo-Fisher finished installing the instrument in collaboration with Gaya Yadav, Ph.D., technical director of the cryo-EM resource; Terry Lovingshimer, Operations Manager for Biochemistry and Biophysics; and Junjie Zhang<\/a>, Ph.D., Associate Professor and faculty director for the resource.<\/p>\n\n\n\n

The LBSB-cryoEM has already generated >30 high-resolution structures after its inauguration in December 2022 with the 1.58A resolution for the ApoF and 1.90Angstrom for a membrane protein and 2.18A for a <80kDa membrane protein in detergent.<\/p>\n\n\n\n

Notable equipment<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n
    \n
  • Krios G4 Cryo-TEM, equipped with autoloader.<\/li>\n\n\n\n
  • Gatan K3 direct electron detector Camera with BioContinuum post-column Imaging filter.<\/li>\n\n\n\n
  • Thermo Fisher Scientific phase plate.<\/li>\n\n\n\n
  • Ceta-D camera for low-dose diffraction data collection.<\/li>\n\n\n\n
  • Vitrobot Mark IV for sample vitrification.<\/li>\n\n\n\n
  • EasiGlow dual system (TedPella) for glow discharging the grids.<\/li>\n\n\n\n
  • GPU-accelerated workstation to process cryo-EM data.<\/li>\n<\/ul>\n\n\n\n

    The laboratory is available to support research within the Texas A&M University System and beyond (academic external and non-academic users).<\/p>\n","protected":false},"excerpt":{"rendered":"

    Adding a rare new capability, the Department of Biochemistry and Biophysics now houses a leading-edge 300 kV cryo-electron microscope. The award-winning Krios G4 provides unrivaled atomic resolution for single-particle and tomographic cryo-electron microscopy. The carefully renovated space for the instrument in the Biochemistry and Biophysics Building was built to minimize vibrations and other interferences. A […]<\/p>\n","protected":false},"author":360,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_genesis_hide_title":true,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"class_list":{"0":"post-7","1":"page","2":"type-page","3":"status-publish","5":"entry"},"acf":[],"featured_image_src":null,"featured_image_src_square":null,"_links":{"self":[{"href":"https:\/\/biochemistry.tamu.edu\/lbsd\/wp-json\/wp\/v2\/pages\/7","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.tamu.edu\/lbsd\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biochemistry.tamu.edu\/lbsd\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.tamu.edu\/lbsd\/wp-json\/wp\/v2\/users\/360"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.tamu.edu\/lbsd\/wp-json\/wp\/v2\/comments?post=7"}],"version-history":[{"count":0,"href":"https:\/\/biochemistry.tamu.edu\/lbsd\/wp-json\/wp\/v2\/pages\/7\/revisions"}],"wp:attachment":[{"href":"https:\/\/biochemistry.tamu.edu\/lbsd\/wp-json\/wp\/v2\/media?parent=7"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}