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September 2017

Biochemistry Seminar – Nick Rhind: “Regulation of Cell Size”

September 27 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Nick Rhind Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School Title: "Regulation of Cell Size" Abstract: Proper cell size is essential for cellular function.  Nonetheless, despite more than 100 years of work on the subject, the mechanisms that maintain cell-size homeostasis are largely mysterious.  Cells in growing populations maintain cell size within a narrow range by coordinating growth and division.  Recent work has proposed two different strategies for size control: budding yeast has been proposed to…

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October 2017

Biochemistry Seminar – Dr. Jay Keasling: Engineered Polyketide Synthases of Commodity and Speciality Chemicals”

October 4 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Jay Keasling Department of Chemical and Biomolecular and of Bioengineering University of California, Berkeley Title: "Engineered Polyketide Synthases for Production of Commodity and Speciality Chemicals" Abstract: Engineered modular polyketide synthases (PKSs) have the potential to be an extraordinarily effective retrosynthesis platform. Native PKSs assemble and tailor simple, readily available cellular acyl-CoAs into large, complex, chiral molecules. By successfully rearranging existing polyketide modules and domains, one could exquisitely control chemical structure from DNA sequence alone. As an example of the…

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Biochemistry Seminar- Joydip Das: “Structure, dynamics and ligand selectivity of C1 domains”

October 11 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Joydip Das Department of Pharmacological and Pharmaceutical Sciences University of Houston Title: "Structure, dynamics and ligand selectivity of C1 domains" Abstract: Engineered modular polyketide synthases (PKSs) have the potential to be an extraordinarily effective retrosynthesis platform. Native PKSs assemble and tailor simple, readily available cellular acyl-CoAs into large, complex, chiral molecules. By successfully rearranging existing polyketide modules and domains, one could exquisitely control chemical structure from DNA sequence alone. As an example of the diverse biosynthetic potential of PKSs,…

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Chenxi Qiu’s Defense

October 12 @ 1:00 pm - 2:00 pm

Title: "Functional dissection of RNA polymerase II active site and mechanism of Action of transcription inhibitor thiolutin" Location: Biochemistry Building, Room 106A Host: Dr. Craig Kaplan

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Roberto A. Crespo’s Defense

October 17 @ 10:00 am - 11:00 am

Title: "Structural and Biochemical Characterization of Inhibitors against Mycobacterium Tuberculosis Adenosine Kinase and Biotin Protein Ligase" Location: ILSB Building room 3147 Host: Dr. Jim Sacchettini  

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Biochemistry Seminar – Fumiaki Katagiri: “Dynamics, mechanisms, and evolution of a highly resilient plant immune signaling network”

October 18 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Fumiaki Katagiri Department of Plant and Microbial Biology University of Minnesota Title: "Dynamics, mechanisms, and evolution of a highly resilient plant immune signaling network" Abstract: "The plant immune signaling network is built highly resilient as well as flexibly tunable, probably to withstand attack from pathogens that can evolve much faster than plants and to balance the immune effect with the negative impact of unnecessarily misfired immune responses. We are studying network structure and dynamics underlying resilience and tunability using…

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Biochemistry Seminar – Jade Wang: “The role of (p)ppGpp in stress response and homeostasis of Gram positive bacteria”

October 25 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Jade Wang Department of Bacteriology University of Wisconsin-Madison Title: "The role of (p)ppGpp in stress response and homeostasis of Gram positive bacteria" Abstract: Bacteria populations often contain rare antibiotic-tolerant persisters which are increasingly recognized as culprits of treatment failures. Wherase mechanisms of persistence have been attributed to the alarmone (p)ppGpp and toxin-antitoxin (TA) systems in Gram-negative bacteria, less is known regarding persister formation in Gram-positive bacteria. We found that antibiotic tolerance of the Gram-positive bacterium Bacillus subtilis is due…

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November 2017

Biochemistry Seminar – Philip West: “Mitochondrial Control of Innate Immunity”

November 1 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Philip West Department of Microbial Pathogenesis and Immunology Texas A&M Health Center Title: "Mitochondrial Control of Innate Immunity" Abstract: As critical participants in cellular energetics, programmed cell death, and signal transduction, mitochondria are important organelles in nearly every cell in the body.  Given these vital roles, mitochondrial dysfunction has been implicated in an ever-growing list of pathologies, including neurodegeneration, cardiovascular disease, cancer, and autoimmunity.  In my seminar, I will detail our ongoing work to delineate how mitochondria act as…

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Biochemistry Seminar – Michael Petris: “Of Mice and Metals: Exploring the roles of copper in health and disease”

November 8 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Micahel Petris Department of Biochemistry University of Missouri Title: "Of Mice and Metals: Exploring the roles of copper in health and disease" Abstract: Copper is an essential heavy metal in eukaryotes. Its accumulation and distribution within cells is tightly regulated to ensure adequate availability for biochemical processes while preventing toxicity.  My laboratory is interested in using biochemical, cell biological and genetic approaches to understanding the roles of nutrient copper in human health with an emphasis on innate immunity and…

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Biochemistry Seminar – Blake Meyers : “The diversity, function, and evolution of secondary siRNA pathways in plants”

November 15 @ 4:00 pm - 5:00 pm
108 Biochemistry Building (Bldg.#1507), 300 Olsen Blvd
College Station, TX 77845 United States
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Dr. Blake Meyers Danforth Center University of Missouri Title: "The diversity, function, and evolution of secondary siRNA pathways in plants" Abstract: My lab has been focused on plant small RNAs for a number of years; most recently, we’ve been investigating the biogenesis, roles, and evolutionary diversification of pathways that give rise to “secondary” small interfering RNAs (siRNAs), more specifically, those triggered by microRNAs and generated in an unusual “phased” pattern. In 2015, we published work from maize in which we…

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