Dr. Wolfgang Peti
Department of Chemistry and Biochemistry
University of Arizona
Title: “Using NMR spectroscopy to unravel enzyme function”
Protein function originates from a cooperation of structural rigidity, dynamics at different timescales and allostery. However, how these three pillars of protein function are integrated is still only poorly understood. Here we show how these pillars are connected in phosphorylation enzymes, specifically the protein tyrosine phosphatase PTP1B and the serine/threonine kinase p38. A broad array of molecular tools are necessary to unravel these function, but NMR plays the key role in analyzing the dynamics that drive the enzymatic cycle as well as allostery that controls enzymatic activity.
Host: Tatyana Igumenova
Location: 108 Biochemistry Building (Bldg#1507)