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Biochemistry Seminar – Wolfgang Peti : “Using NMR spectroscopy to unravel enzyme function”

March 21, 2018 @ 4:00 pm - 5:00 pm

Dr. Wolfgang Peti

Department of Chemistry and Biochemistry

University of Arizona

Title: “Using NMR spectroscopy to unravel enzyme function”


Protein function originates from a cooperation of structural rigidity, dynamics at different timescales and allostery. However, how these three pillars of protein function are integrated is still only poorly understood. Here we show how these pillars are connected in phosphorylation enzymes, specifically the protein tyrosine phosphatase PTP1B and the serine/threonine kinase p38. A broad array of molecular tools are necessary to unravel these function, but NMR plays the key role in analyzing the dynamics that drive the enzymatic cycle as well as allostery that controls enzymatic activity.

Host: Tatyana Igumenova

Location: 108 Biochemistry Building (Bldg#1507)


March 21, 2018
4:00 pm - 5:00 pm
Event Category:


Tatyana Igumenova


108 Biochemistry Building (Bldg.#1507)
300 Olsen Blvd
College Station, TX 77845 United States
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