Department of Medicine
Title: “CNC and MAF transcription factors: stress, cancer, knock outs and other serious matter”
Abstract: Our research focuses on the role of members of the CNC (cap’n’collar) and small MAF (musculoaponeurotic fibrosarcoma) families of basic leucine zipper transcription factors. These proteins play important roles in the regulation of mammalian gene expression. CNC and small MAF proteins can form heterodimers, and the resulting complexes bind to ARE (antioxidant response element) type of DNA recognition sequences. Intracellular regulation of CNC and small MAF proteins is complex and provides interesting means to fine-tune the transcriptional control by these regulatory proteins. Importantly, CNC and MAF proteins play key roles in the cellular stress response as well as in variety of human pathologies, including various types of cancer.
Host: Mike Manson