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Biochemistry Seminar – Yinghao Wu : “Understand Binding Kinetics of Membrane Receptors and Their Functional Roles in Cell adhesion and Signaling by Multi-scale Modeling”
October 10, 2018 @ 4:00 pm - 5:00 pm
Yinghao Wu, Ph.D.
Department of Systems and Computational Biology
Albert Einstein College of Medicine
Title: “Understand Binding Kinetics of Membrane Receptors and Their Functional Roles in Cell adhesion and Signaling by Multi-scale Modeling”
Abstract: Membrane receptors on cell surfaces constitute a majority of approved drug targets on the pharmaceutical market. In most cases, they bind to extracellular ligands and initiate various intracellular signaling pathways. This process underlies many cellular activities such as adhesion and apoptosis. However, our understanding to the cellular functions of membrane receptors is largely limited by the fact that in vivo binding of receptors has only been successfully measured in a very small number of cases. Most experimental methods isolate receptors and ligands from their biological surrounding in order to permit a more convenient analysis. In living cells, receptors are anchored on surfaces of plasma membrane. The membrane confinement significantly affects binding kinetics of receptors. Moreover, binding can also be regulated by the flexibility and multi-valency of receptors or ligands. These multi-level complexities lead to the difficulty in quantifying binding kinetics of membrane receptors on cell surfaces. Computational modeling can reach dimensions that are currently unapproachable in the laboratory. Thus, our lab are currently developing computational models at different levels to understand the physical process of binding between cell surface receptors and their ligand, and the impacts of these interactions in the biological processes of cell adhesion and cell signaling. We are specifically interested in answering the following two questions: how membrane confinement and other cellular heterogeneity affect binding between receptors and ligands, and how the spatial organization of membrane receptors regulates downstream signaling pathways.
Host: Junjie Zhang
Location: 108 Biochemistry Building (Bldg#1507)