Department of Biochemistry
University of Nebraska
Title: “Proteolytic control of mitochondrial shape and function”
Abstract: Mitochondrial quality control (MQC) proteases are pivotal to mitochondrial functions and integrity. Despite their significance, our understanding of the multifaceted physiological roles and modus operandi of many MQC enzymes remains limited. Work in our lab, which focused mainly on the key MQC protease Oma1, used yeast and mammalian cell culture models and a blend of genetic, mechanistic biochemistry, and molecular cell biology approaches to: 1) show how dormant Oma1 is activated by homeostatic insults, 2) delineate Oma1’s role in the metabolic fine-tuning of mitochondria, and 3) show how loss of Oma1 function alters mitochondrial signaling outputs and impacts other MQC proteins. These studies advanced our understanding of MQC role in mitochondrial wellbeing and provided insights into how these modules cooperate to maintain physical and functional integrity of the organelle. As defects in MQC components are linked to prevalent neurodegenerative and cardiovascular disorders, our studies provide new molecular targets and strategies for treating these maladies.
Host: Vishal Gohil
Location: 108 Biochemistry Building (Bldg#1507)