Dr. Xindan Wang
Department of Biology
Title: “How Condensin Compacts and Resolves Chromosomes in Bacillus subtilis”
Chromosome compaction, organization and faithful segregation is fundamental to the life process. In virtually all organisms, the SMC condensin complexes play a critical role in compacting and resolving replicated chromosomes, yet how they accomplish this remains poorly understood. In Bacillus subtilis, condensin is loaded at centromeric parS sites, where it encircles DNA and individualizes newly replicated origins. We use genetics, fluorescence microscopy and Chromosome Conformation Capture (Hi-C) methodologies to study the role of the highly conserved partitioning system and the SMC condensin complex in chromosome segregation.
Host: Jennifer Herman
Location: 108 Biochemistry Building (Bldg#1507)