Department of Biological Sciences
Florida State University
Title: “Subversion of cGAS-STING DNA sensing by Kaposi sarcoma-associated herpesvirus”
Abstract: Cytosolic DNAs of self or foreign are immuno-stimulatory that can be recognized by the host innate immune sensors. Among them cGAS (cyclic GMP-AMP synthase) is the principal one that upon binding to DNA can catalyze the synthesis of the cGAMP, a second messenger directs the adaptor protein STING to stimulate interferon immune responses. The cGAS-STING pathway plays a crucial role not only in anti-viral defenses but also anti-tumor immunity, and cGAS-STING agonists exert potent anti-tumor effects. Kaposi’s sarcoma-associated herpesvirus (KSHV) is a large DNA tumor virus that causes Kaposi sarcoma (KS) and other human cancers. To persist in the host, the virus must overcome the host defenses including avoidance of sensing of viral DNAs. In this presentation, I will talk about how KSHV evades DNA-sensing by the host cGAS-STING pathway.
Host: Pingwei Li
Location: 108 Biochemistry Building (Bldg#1507)