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Biochemistry Seminar – Dr. Sheng Luan: “TBA”
March 4 @ 4:00 pm - 5:00 pm
Dr. Sheng Luan
Department of Plant & Microbial Biology
University of California, Berkeley
Title:”Regulation of nutrient homeostasis by a calcium signaling network”
Almost all signal transduction processes in plants involve Ca2+ that serve as a vital second messenger. Understanding how Ca2+ mediates the cellular responses triggered by myriad environmental signals is one of the most important goals for plant biologists in years to come. Recent studies uncovered a new family of Ca2+ sensors (CBLs) that target a family of protein kinases (CIPKs), establishing a novel paradigm for Ca2+ signaling in plants. The CBL calcium sensors and CIPK protein kinases are encoded by two multigene families. In Arabidopsis (with the smallest genome among flower plants), at least 10 CBLs and 26 CIPKs are identified. Each CBL interacts with a selected repertoire of CIPKs and each CIPK interacts with one or more CBLs. Some CBLs have common CIPK targets and some CIPKs share CBL regulatory proteins. Such specific and overlapping scheme in the CBL-CIPK interaction suggests both specific and redundant functions among the members of the two gene families. Genetic analysis has begun to reveal the function of individual CBLs and CIPKs. Available results indicate that CBL-CIPK interactions form an extensive network that functions in a number of signaling pathways including plant responses to abiotic stress, nutrition status, and abscisic acid (ABA). In addition, more recent work identified protein phosphatases that down-regulate the pathways activated by CBL-CIPK network and other kinases. In particular, ion channels serve as targets for such regulations in which kinases and phosphatases form specific pairs. Examples and mechanisms of ion channel regulation by CBL-CIPK network will be presented.
Host: Ping He
108 Biochemistry Building (Bldg#1507)