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Biochemistry Seminar – Dr. Alexander Mankin: “Stopping the ribosome at the finish line: how PrAMPs inhibit termination of translation”
November 6 @ 4:00 pm - 5:00 pm
Dr. Alexander Mankin
Center for Biomolecular Sciences
University of Illinois at Chicago
Title: “Stopping the ribosome at the finish line: how PrAMPs inhibit termination of translation”
Abstract:Apidaecin (Api), produced by honeybees, belongs to the class of proline-rich antimicrobial peptides (PrAMPs), which protect the host from bacterial infection. Api has a unique mode of action and stops bacteria from growing by inhibiting the termination step of translation. Biochemical, genetic and genomic analyses show that the action of Api is distinct from the action of other ribosome inhibitors. Lessons learned from studying Api may illuminate the unknown aspects of cell physiology and may open novel approaches for treatment of human diseases.
Host: Paul Straight
108 Biochemistry Building (Bldg.#1507)