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Biochemistry Seminar – Dr. Alexander Mankin: “Stopping the ribosome at the finish line: how PrAMPs inhibit termination of translation”

November 6 @ 4:00 pm - 5:00 pm

Dr. Alexander Mankin

Center for Biomolecular Sciences

University of Illinois at Chicago

Title: “Stopping the ribosome at the finish line: how PrAMPs inhibit termination of translation”

Abstract:Apidaecin (Api), produced by honeybees, belongs to the class of proline-rich antimicrobial peptides (PrAMPs), which protect the host from bacterial infection. Api has a unique mode of action and stops bacteria from growing by inhibiting the termination step of translation. Biochemical, genetic and genomic analyses show that the action of Api is distinct from the action of other ribosome inhibitors. Lessons learned from studying Api may illuminate the unknown aspects of cell physiology and may open novel approaches for treatment of human diseases.

Host: Paul Straight

108 Biochemistry Building (Bldg.#1507)

Details

Date:
November 6
Time:
4:00 pm - 5:00 pm
Event Category:

Organizer

Paul Straight

Venue

108 Biochemistry Building (Bldg.#1507)
300 Olsen Blvd
College Station, TX 77845 United States
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