There are new metabolomics services available at Texas A&M. Larry Dangott (Dept of Biochemistry & Biophysics and The Protein Chemistry Laboratory (PCL)) and Arul Jayaraman (Dept of Chemical Engineering) were recently awarded $1.55M by the Research Development Fund (of the OVPR) to expand the PCL capabilities and establish the Integrated Metabolomics Analysis Core (IMAC) for the analysis of metabolites and other small molecules. The laboratory is located in space generously provided by the BioBio Department alongside the PCL on the fourth floor of BioBio (room 402). The funding was used to purchase three new mass spectrometers and ancillary equipment, and hire two new, full time, staff people. The laboratory manager, Dr. Cory Klemashevich, is a (three degree) graduate of Texas A&M and has extensive experience in targeted metabolomics analysis. Cory joined the IMAC staff on July 1 and has been actively setting up the lab and getting trained on the new instruments. Please say “Howdy” to Cory when you see him around the department.
The IMAC has two LCMS instruments and one GCMS instrument, all from ThermoScientific. The QExactive Plus OrbiTrap is a High Resolution/Accurate Mass instrument that will be used for ‘untargeted’ metabolomics studies using our in-house Compound Discoverer software and molecular structure libraries. The TSQ Quantiva is a triple quadrupole instrument that will be used for ‘targeted’, quantitative analysis. Both instruments are LCMS systems (liquid chromatography-MS) with dedicated LC systems for each. The third instrument is a TSQ 8000 Evo GCMS (gas chromatography-MS) and is also a triple quadrupole instrument that will be used for ‘untargeted’ and ‘targeted’ analysis of volatile analytes that are not amenable to liquid chromatography. All instruments are controlled with the latest version of Trace Finder control and analysis software. In addition, the laboratory is equipped with all the small instrumentation required for the extraction of a variety of sample types (serum, plasma, tissue, organ, feces, organism) and is eager to help students and postdocs learn or develop extraction methods to fit their needs.
Although service and research are foremost, education and training are an important part of the mission of the IMAC (as it is in the PCL) and, as such, the IMAC will be presenting training workshops and seminars on a variety of metabolomics related topics, some presented by nationally recognized experts in the field. Metabolomics studies often require large sample sets, so it is planned that selected students/postdocs with large projects will become trained on the instruments and be allowed supervised use of the instruments. Even if students do not run the instruments, there will be training on the bioinformatics software and libraries housed on our new in-house server for data processing. The IMAC possesses multiple software licenses of Trace Finder and Compound Discoverer, so several users can analyze data remotely, and simultaneously.
We invite you to contact Cory (845-4832, firstname.lastname@example.org) or visit the IMAC to set up an appointment to discuss your metabolomics analysis needs. Also, check out our new website (imac.tamu.edu) for additional information and details about project interviews, protocols, sample submission, policies and fees.