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Michael Polymenis

Polymenis, Michael
Michael Polymenis
Professor
Office:
BioBio / Room 333A
Email:
Phone:
979-458-3259
https://sites.google.com/site/thepolymenislab
Undergraduate Education
B.S. University of Patras, Greece (1988)
Graduate Education
Ph.D. Tufts University Medical School (1994)
Postdoc. Massachusetts General Hospital Cancer Center, Harvard Medical School (1995-1999)
Joined Texas A&M in 1999

Coordination of Cell growth with Cell Division

The promise for the treatment of proliferative disorders, with incalculable potential benefits to human health, has driven basic research into the genetic control of cell division for decades. However, what determines when cells initiate their division remains mysterious. It is as if we are staring at a beautiful engine, with little knowledge about what turns it on. How cells are set off to a new round of cell division, remains as one of the most fundamental, unanswered questions. It is virtually unknown which cellular pathways affect initiation of division, which factors operate within each pathway, the extent of interactions between pathways, and how each pathway is molecularly linked to the machinery of cell division. Our studies aim to answer these questions using baker’s yeast. This model organism has a machinery of cell division that is very similar to that of human cells, and it is suited for genetic and biochemical studies.

Recent Publications

  1. Mohler, K, Mann, R, Bullwinkle, TJ, Hopkins, K, Hwang, L, Reynolds, NM et al.. Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Nucleic Acids Res. 2017; :.
    doi: 10.1093/nar/gkx077. PubMed PMID:28168297. .

  2. Blank, HM, Perez, R, He, C, Maitra, N, Metz, R, Hill, J et al.. Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells. EMBO J. 2017;36 (4):487-502.
    doi: 10.15252/embj.201695050. PubMed PMID:28057705. .

  3. He, C, Tsuchiyama, SK, Nguyen, QT, Plyusnina, EN, Terrill, SR, Sahibzada, S et al.. Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS Genet. 2014;10 (12):e1004860.
    doi: 10.1371/journal.pgen.1004860. PubMed PMID:25521617. PubMed Central PMC4270464.

  4. Park, J, Wu, J, Polymenis, M, Han, A. Microchemostat array with small-volume fraction replenishment for steady-state microbial culture. Lab Chip. 2013;13 (21):4217-24.
    doi: 10.1039/c3lc50665g. PubMed PMID:23986263. .

  5. Truong, SK, McCormick, RF, Polymenis, M. Genetic determinants of cell size at birth and their impact on cell cycle progression in Saccharomyces cerevisiae. G3 (Bethesda). 2013;3 (9):1525-30.
    doi: 10.1534/g3.113.007062. PubMed PMID:23821617. PubMed Central PMC3755912.

  6. Hoose, SA, Trinh, JT, Leitch, MC, Kelly, MM, McCormick, RF, Spyrou, CL et al.. Saccharomyces cerevisiae deletion strains with complex DNA content profiles. FEMS Microbiol. Lett. 2013;345 (1):72-6.
    doi: 10.1111/1574-6968.12186. PubMed PMID:23714007. .

  7. Polymenis, M, Kennedy, BK. Chronological and replicative lifespan in yeast: do they meet in the middle? Cell Cycle. 2012;11 (19):3531-2.
    doi: 10.4161/cc.22041. PubMed PMID:22951539. PubMed Central PMC3478299.

  8. Polymenis, M, Kennedy, BK. Cell biology: High-tech yeast ageing. Nature. 2012;486 (7401):37-8.
    doi: 10.1038/486037a. PubMed PMID:22678274. .

  9. Hoose, SA, Duran, C, Malik, I, Eslamfam, S, Shasserre, SC, Downing, SS et al.. Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine. PLoS ONE. 2012;7 (5):e36503.
    doi: 10.1371/journal.pone.0036503. PubMed PMID:22567160. PubMed Central PMC3342239.

  10. Hoose, SA, Rawlings, JA, Kelly, MM, Leitch, MC, Ababneh, QO, Robles, JP et al.. A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet. 2012;8 (3):e1002590.
    doi: 10.1371/journal.pgen.1002590. PubMed PMID:22438835. PubMed Central PMC3305459.

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