- Undergraduate Education
- B.S. University of Patras, Greece (1988)
- Graduate Education
- Ph.D. Tufts University Medical School (1994)
- Postdoc. Massachusetts General Hospital Cancer Center, Harvard Medical School (1995-1999)
- Joined Texas A&M in 1999
Coordination of Cell growth with Cell Division
The promise for the treatment of proliferative disorders, with incalculable potential benefits to human health, has driven basic research into the genetic control of cell division for decades. However, what determines when cells initiate their division remains mysterious. It is as if we are staring at a beautiful engine, with little knowledge about what turns it on. How cells are set off to a new round of cell division, remains as one of the most fundamental, unanswered questions. It is virtually unknown which cellular pathways affect initiation of division, which factors operate within each pathway, the extent of interactions between pathways, and how each pathway is molecularly linked to the machinery of cell division. Our studies aim to answer these questions using baker’s yeast. This model organism has a machinery of cell division that is very similar to that of human cells, and it is suited for genetic and biochemical studies.
Mohler, K, Mann, R, Bullwinkle, TJ, Hopkins, K, Hwang, L, Reynolds, NM et al.. Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Nucleic Acids Res. 2017; :.
Blank, HM, Perez, R, He, C, Maitra, N, Metz, R, Hill, J et al.. Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells. EMBO J. 2017;36 (4):487-502.
He, C, Tsuchiyama, SK, Nguyen, QT, Plyusnina, EN, Terrill, SR, Sahibzada, S et al.. Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS Genet. 2014;10 (12):e1004860.
Park, J, Wu, J, Polymenis, M, Han, A. Microchemostat array with small-volume fraction replenishment for steady-state microbial culture. Lab Chip. 2013;13 (21):4217-24.
Truong, SK, McCormick, RF, Polymenis, M. Genetic determinants of cell size at birth and their impact on cell cycle progression in Saccharomyces cerevisiae. G3 (Bethesda). 2013;3 (9):1525-30.
Hoose, SA, Trinh, JT, Leitch, MC, Kelly, MM, McCormick, RF, Spyrou, CL et al.. Saccharomyces cerevisiae deletion strains with complex DNA content profiles. FEMS Microbiol. Lett. 2013;345 (1):72-6.
Polymenis, M, Kennedy, BK. Chronological and replicative lifespan in yeast: do they meet in the middle? Cell Cycle. 2012;11 (19):3531-2.
Polymenis, M, Kennedy, BK. Cell biology: High-tech yeast ageing. Nature. 2012;486 (7401):37-8.
Hoose, SA, Duran, C, Malik, I, Eslamfam, S, Shasserre, SC, Downing, SS et al.. Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine. PLoS ONE. 2012;7 (5):e36503.
Hoose, SA, Rawlings, JA, Kelly, MM, Leitch, MC, Ababneh, QO, Robles, JP et al.. A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet. 2012;8 (3):e1002590.