- Undergraduate Education
- B.Sc. Mohan Lal Sukhadia University, India (1995)
- Graduate Education
- M.Sc. Maharaja Sayajirao University of Baroda, India (1997)
- Ph.D. Wayne State University, Detroit (2005)
- Postdoc. Massachusetts General Hospital, Boston (2005-2008)
- Instructor in Medicine, Harvard Medical School, Boston (2008-2011)
- Joined Texas A&M in 2012
Mitochondrial Biogenesis and Energy Metabolism
Our long-term research objective is to understand the biogenesis of mitochondrial respiratory chain (MRC) complexes. The MRC is present in the inner mitochondrial membrane and is the main site for cellular respiration and energy production. It consists of five multi-protein complexes composed of ~90 subunits that assemble into supra-molecular structures called supercomplexes. MRC biogenesis is a complex, multi-step process facilitated by hundreds of uncharacterized factors. Despite insights gained through decades of research on mitochondrial bioenergetics, our understanding of MRC biogenesis is incomplete, and many fundamental questions remain unanswered. For example, what factors are required for the formation and stabilization of MRC complexes and supercomplexes? What role does the lipid milieu play in MRC complex assembly? We have two ongoing projects that will address these important questions using the tools of genomics, genetics, and biochemistry in human cells and the yeast Saccharomyces cerevisiae.
Baker, CD, Basu Ball, W, Pryce, EN, Gohil, VM. Specific requirements of nonbilayer phospholipids in mitochondrial respiratory chain function and formation. Mol. Biol. Cell. 2016;27 (14):2161-71.
Tomar, D, Dong, Z, Shanmughapriya, S, Koch, DA, Thomas, T, Hoffman, NE et al.. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Cell Rep. 2016;15 (8):1673-85.
Ghosh, A, Pratt, AT, Soma, S, Theriault, SG, Griffin, AT, Trivedi, PP et al.. Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis. Hum. Mol. Genet. 2016;25 (4):660-71.
Kishi, S, Campanholle, G, Gohil, VM, Perocchi, F, Brooks, CR, Morizane, R et al.. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015;2 (9):1090-101.
Ghosh, A, Trivedi, PP, Timbalia, SA, Griffin, AT, Rahn, JJ, Chan, SS et al.. Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Hum. Mol. Genet. 2014;23 (13):3596-606.
Jhurry, ND, Chakrabarti, M, McCormick, SP, Gohil, VM, Lindahl, PA. Mössbauer study and modeling of iron import and trafficking in human jurkat cells. Biochemistry. 2013;52 (45):7926-42.
Gohil, VM, Zhu, L, Baker, CD, Cracan, V, Yaseen, A, Jain, M et al.. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J. Biol. Chem. 2013;288 (49):35387-95.
Patil, VA, Fox, JL, Gohil, VM, Winge, DR, Greenberg, ML. Loss of cardiolipin leads to perturbation of mitochondrial and cellular iron homeostasis. J. Biol. Chem. 2013;288 (3):1696-705.
Gohil, VM, Offner, N, Walker, JA, Sheth, SA, Fossale, E, Gusella, JF et al.. Meclizine is neuroprotective in models of Huntington's disease. Hum. Mol. Genet. 2011;20 (2):294-300.
Perocchi, F, Gohil, VM, Girgis, HS, Bao, XR, McCombs, JE, Palmer, AE et al.. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 2010;467 (7313):291-6.