Biochemistry & Biophysics

Magnus Hook

hook Professor of Biochemistry and Biophysics, of the IBT-Houston, and of Veterinary Anatomy and Public Health
Director, Center for Extracellular Matrix Biology

Phone: (713) 677- 7551
Email: mhook@ibt.tamu.edu
Visit the Hook lab Home Page
B.S. University of Uppsala, Sweden (1971)
Ph.D. University of Uppsala, Sweden (1974)

Joined Texas A&M faculty in 1992

Microbial Pathogenesis / Virulence Factors / Cell Adhesion
The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.

Recent Publications
  1. Barbu EM, Ganesh VK, Gurusiddappa S, Mackenzie RC, Foster TJ, Sudhof TC & Höök M (2010) beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. PLoS Pathog 6: e1000726
  2. Nuka S, Zhou W, Henry SP, Gendron CM, Schultz JB, Shinomura T, Johnson J, Wang Y, Keene DR, Ramírez-Solis R, Behringer RR, Young MF & Höök M (2010) Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage 18: 88-96
  3. Sillanpää J, Nallapareddy SR, Houston J, Ganesh VK, Bourgogne A, Singh KV, Murray BE & Höök M (2009) A family of fibrinogen-binding MSCRAMMs from Enterococcus faecalis. Microbiology 155: 2390-400
  4. Evans SE, Scott BL, Clement CG, Larson DT, Kontoyiannis D, Lewis RE, Lasala PR, Pawlik J, Peterson JW, Chopra AK, Klimpel G, Bowden G, Höök M, Xu Y, Tuvim MJ & Dickey BF (2010) Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol 42: 40-50
  5. Ganesh VK, Rivera JJ, Smeds E, Ko YP, Bowden MG, Wann ER, Gurusiddappa S, Fitzgerald JR & Höök M (2008) A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. PLoS Pathog 4: e1000226
  6. Sillanpää J, Nallapareddy SR, Prakash VP, Qin X, Höök M, Weinstock GM & Murray BE (2008) Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium. Microbiology 154: 3199-211
  7. Seo NS, Zeng CQ, Hyser JM, Utama B, Crawford SE, Kim KJ, Höök M & Estes MK (2008) Inaugural article: integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A 105: 8811-8
  8. Ferdous Z, Lazaro LD, Iozzo RV, Höök M & Grande-Allen KJ (2008) Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices. Biomaterials 29: 2740-8
  9. Bowden MG, Heuck AP, Ponnuraj K, Kolosova E, Choe D, Gurusiddappa S, Narayana SV, Johnson AE & Höök M (2008) Evidence for the "dock, lock, and latch" ligand binding mechanism of the staphylococcal microbial surface component recognizing adhesive matrix molecules (MSCRAMM) SdrG. J Biol Chem 283: 638-47
  10. Ferdous Z, Wei VM, Iozzo R, Höök M & Grande-Allen KJ (2007) Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices. J Biol Chem 282: 35887-98
  11. Rivera J, Vannakambadi G, Höök M & Speziale P (2007) Fibrinogen-binding proteins of Gram-positive bacteria. Thromb Haemost 98: 503-11
  12. Nallapareddy SR, Sillanpää J, Ganesh VK, Höök M & Murray BE (2007) Inhibition of Enterococcus faecium adherence to collagen by antibodies against high-affinity binding subdomains of Acm. Infect Immun 75: 3192-6
  13. Liu Q, Ponnuraj K, Xu Y, Ganesh VK, Sillanpää J, Murray BE, Narayana SV & Höök M (2007) The Enterococcus faecalis MSCRAMM ACE binds its ligand by the Collagen Hug model. J Biol Chem 282: 19629-37
  14. Labandeira-Rey M, Couzon F, Boisset S, Brown EL, Bes M, Benito Y, Barbu EM, Vazquez V, Höök M, Etienne J, Vandenesch F & Bowden MG (2007) Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 315: 1130-3
  15. Dugan TA, Yang VW, McQuillan DJ & Höök M (2006) Decorin modulates fibrin assembly and structure. J Biol Chem 281: 38208-16
  16. Nallapareddy SR, Singh KV, Sillanpää J, Garsin DA, Höök M, Erlandsen SL & Murray BE (2006) Endocarditis and biofilm-associated pili of Enterococcus faecalis. J Clin Invest 116: 2799-807
  17. Seo NS, McQuillan DJ & Höök M (2006) The role of glycosylation in the secretion of proteoglycans. ScientificWorldJournal 6: 491-3
  18. Chen CH, Yeh ML, Geyer M, Wang GJ, Huang MH, Heggeness MH, Höök M & Luo ZP (2006) Interactions between collagen IX and biglycan measured by atomic force microscopy. Biochem Biophys Res Commun 339: 204-8
  19. Seo NS, Hocking AM, Höök M & McQuillan DJ (2005) Decorin core protein secretion is regulated by N-linked oligosaccharide and glycosaminoglycan additions. J Biol Chem 280: 42774-84
  20. Kim JK, Xu Y, Xu X, Keene DR, Gurusiddappa S, Liang X, Wary KK & Höök M (2005) A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1. J Biol Chem 280: 32512-20
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