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Biochem - Week of 2/07/2010
Wed Feb 10 2010 4:00 PMBioBio 108
Speaker: New Event
Title tba
Tuesday's hot paper
Hall RS, Fedorov AA, Marti-Arbona R, Fedorov EV, Kolb P, Sauder JM, Burley SK, Shoichet BK, Almo SC & Raushel FM (2010) The Hunt for 8-Oxoguanine Deaminase. J Am Chem SocChanges daily; picked from the most recent notable papers from BioBio labs.
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The Shippen lab studies telomere function, maintenance and formation.Telomeres prevent chromosome ends from being identified as broken DNA and repaired. The telomerase enzyme in Arabidopsis has several components including a RNA molecule that contains a template region and a protein called telomerase reverse transcriptase (TERT) that uses the sequence on the RNA to add the complementary DNA sequence to the chromosome end. These two subunits and the various other components have to be assembled before telomerase is able to function. In this image, TERT molecules in Arabidopsis nuclei are visualized by immunofluorescence. The Tert molecules are located in the nucleolus, the same place that ribosomes are put together.